5,6-dimethylbenzimidazole synthase
5,6-dimethylbenzimidazole synthase | |||||||||
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Identifiers | |||||||||
EC number | 1.14.99.40 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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5,6-dimethylbenzimidazole synthase (EC 1.14.99.40, BluB) is an enzyme with systematic name FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming).[1][2][3] This enzyme catalyses the following chemical reaction
- FMNH2 + NADH + H+ + O2 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + other product
The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen.
References
- ↑ Gray, M.J.; Escalante-Semerena, J.C. (2007). "Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12". Proc. Natl. Acad. Sci. USA. 104 (8): 2921–2926. doi:10.1073/pnas.0609270104. PMC 1815282. PMID 17301238.
- ↑ Ealick, S.E.; Begley, T.P. (2007). "Biochemistry: molecular cannibalism". Nature. 446 (7134): 387–388. doi:10.1038/446387a. PMID 17377573.
- ↑ Taga, M.E.; Larsen, N.A.; Howard-Jones, A.R.; Walsh, C.T.; Walker, G.C. (2007). "BluB cannibalizes flavin to form the lower ligand of vitamin B12". Nature. 446 (7134): #449–453. doi:10.1038/nature05611. PMC 2770582. PMID 17377583.
External links
- 5,6-dimethylbenzimidazole synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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