5,6-dimethylbenzimidazole synthase

5,6-dimethylbenzimidazole synthase
Identifiers
EC number 1.14.99.40
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

5,6-dimethylbenzimidazole synthase (EC 1.14.99.40, BluB) is an enzyme with systematic name FMNH2 oxidoreductase (5,6-dimethylbenzimidazole forming).[1][2][3] This enzyme catalyses the following chemical reaction

FMNH2 + NADH + H+ + O2 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + other product

The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen.

References

  1. Gray, M.J.; Escalante-Semerena, J.C. (2007). "Single-enzyme conversion of FMNH2 to 5,6-dimethylbenzimidazole, the lower ligand of B12". Proc. Natl. Acad. Sci. USA. 104 (8): 2921–2926. doi:10.1073/pnas.0609270104. PMC 1815282Freely accessible. PMID 17301238.
  2. Ealick, S.E.; Begley, T.P. (2007). "Biochemistry: molecular cannibalism". Nature. 446 (7134): 387–388. doi:10.1038/446387a. PMID 17377573.
  3. Taga, M.E.; Larsen, N.A.; Howard-Jones, A.R.; Walsh, C.T.; Walker, G.C. (2007). "BluB cannibalizes flavin to form the lower ligand of vitamin B12". Nature. 446 (7134): #449–453. doi:10.1038/nature05611. PMC 2770582Freely accessible. PMID 17377583.

External links

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