ADK (gene)

ADK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BX4, 2I6A, 2I6B, 4O1L
Identifiers
Aliases	ADK, Adk, 2310026J05Rik, 5033405D03Rik, AI255373, AI987814, Ak, adenosine kinase
External IDs	MGI: 87930 HomoloGene: 4891 GeneCards: ADK
Gene ontology Molecular function • transferase activity • nucleotide binding • metal ion binding • kinase activity • phosphotransferase activity, alcohol group as acceptor • poly(A) RNA binding • ATP binding • adenosine kinase activity Cellular component • cytosol • nucleoplasm • nucleus • cytoplasm Biological process • purine ribonucleoside salvage • phosphorylation • adenosine metabolic process • purine-containing compound salvage • circadian regulation of gene expression • positive regulation of cardiac muscle hypertrophy • ribonucleoside monophosphate biosynthetic process • AMP salvage • positive regulation of T cell proliferation • dATP biosynthetic process • AMP biosynthetic process • type B pancreatic cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	132	11534
Ensembl	ENSG00000156110	ENSMUSG00000039197
UniProt	P55263	P55264
RefSeq (mRNA)	NM_001123 NM_001202449 NM_001202450 NM_006721	NM_001243041 NM_134079
RefSeq (protein)	NP_001114.2 NP_001189378.1 NP_001189379.1 NP_006712.2	NP_001229970.1 NP_598840.1
Location (UCSC)	Chr 10: 74.15 – 74.71 Mb	Chr 14: 21.05 – 21.45 Mb
PubMed search	[1]	[2]
Wikidata

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Adenosine kinase is an enzyme that in humans is encoded by the ADK gene.^[3][4]

Function

This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg²⁺ for activity.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS (Mar 1996). "Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases". Proc Natl Acad Sci U S A. 93 (3): 1232–7. doi:10.1073/pnas.93.3.1232. PMC 40062. PMID 8577746.
4. "Entrez Gene: ADK adenosine kinase".

External links

• Human ADK genome location and ADK gene details page in the UCSC Genome Browser.

Further reading

• Klobutcher LA, Nichols EA, Kucherlapati RS, Ruddle FH (1976). "Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel.". Cytogenet. Cell Genet. 16 (1–5): 171–4. doi:10.1159/000130582. PMID 185014.
• Singh B, Hao W, Wu Z, et al. (1996). "Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene". Eur. J. Biochem. 241 (2): 564–71. doi:10.1111/j.1432-1033.1995.tb20220.x_1. PMID 8917457.
• McNally T, Helfrich RJ, Cowart M, et al. (1997). "Cloning and expression of the adenosine kinase gene from rat and human tissues". Biochem. Biophys. Res. Commun. 231 (3): 645–50. doi:10.1006/bbrc.1997.6157. PMID 9070863.
• Mathews II, Erion MD, Ealick SE (1998). "Structure of human adenosine kinase at 1.5 A resolution". Biochemistry. 37 (45): 15607–20. doi:10.1021/bi9815445. PMID 9843365.
• Van Rompay AR, Johansson M, Karlsson A (1999). "Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein". Eur. J. Biochem. 261 (2): 509–17. doi:10.1046/j.1432-1327.1999.00294.x. PMID 10215863.
• Singh B, Lin A, Wu ZC, Gupta RS (2001). "Gene structure for adenosine kinase in Chinese hamster and human: high-frequency mutants of CHO cells involve deletions of several introns and exons". DNA Cell Biol. 20 (1): 53–65. doi:10.1089/10445490150504693. PMID 11242543.
• Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics. 2 (6): 642–8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.