AG 489
Names | |
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IUPAC name
N-[3-[3-[3-[4-(3-aminopropylamino) butylamino] propylamino]propyl-hydroxyamino] propyl]-2-(1H-indol-3-yl)acetamide | |
Other names
Agatoxin 489 | |
Identifiers | |
128549-96-2 | |
3D model (Jmol) | Interactive image |
ChemSpider | 115840 |
2484 | |
PubChem | 131007 |
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Properties | |
C26H47N7O2 | |
Molar mass | 489.69708 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
AG 489 (or agatoxin 489) is a component of the venom produced by Agelenopsis aperta.[1] It inhibits the ligand gated ion channel TRPV1 through a pore blocking mechanism.[2]
References
- ↑ Herold EE, Yaksh TL (1992). "Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat". Anesthesiology. 77 (3): 507–12. doi:10.1097/00000542-199209000-00016. PMID 1519789.
- ↑ Kitaguchi T, Swartz KJ (2005). "An inhibitor of TRPV1 channels isolated from funnel Web spider venom". Biochemistry. 44 (47): 15544–9. doi:10.1021/bi051494l. PMID 16300403.
See also
External links
- AG 489 at the US National Library of Medicine Medical Subject Headings (MeSH)
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