AHNAK

AHNAK
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4DRW, 4FTG, 4HRG
Identifiers
Aliases	AHNAK, AHNAKRS, AHNAK nucleoprotein
External IDs	MGI: 1316648 HomoloGene: 67425 GeneCards: AHNAK
Gene ontology Molecular function • S100 protein binding • structural molecule activity conferring elasticity • protein binding • poly(A) RNA binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • vesicle • cytosol • membrane • cell-cell contact zone • focal adhesion • T-tubule • plasma membrane • lysosomal membrane • actin cytoskeleton • membrane raft • sarcolemma • costamere • extracellular exosome • nucleus • cell-cell adherens junction Biological process • regulation of voltage-gated calcium channel activity • regulation of RNA splicing • protein oligomerization • cell-cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79026	66395
Ensembl	ENSG00000124942	ENSMUSG00000069833
UniProt	Q09666	n/a
RefSeq (mRNA)	NM_001620 NM_024060	NM_001039959 NM_001286518 NM_009643 NM_175108
RefSeq (protein)	NP_001611.1 NP_076965.2	n/a
Location (UCSC)	Chr 11: 62.43 – 62.56 Mb	Chr 19: 8.99 – 9.08 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene.^[3][4][5] AHNAK was originally identified in 1989 (in bovine muzzle epidermal cells) and named desmoyokin due to its localization pattern (that resembled a yoke) in the desmosomal plaque.^[6] AHNAK has been shown to be essential for pseudopod protrusion and cell migration. ^[7]

Interactions

AHNAK has been shown to interact with S100B.^[8]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. James MR, Richard CW III, Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A, et al. (Jan 1995). "A radiation hybrid map of 506 STS markers spanning human chromosome 11". Nat Genet. 8 (1): 70–6. doi:10.1038/ng0994-70. PMID 7987395.
4. Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H (Aug 2002). "The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton". FASEB J. 16 (10): 1205–16. doi:10.1096/fj.01-0855com. PMID 12153988.
5. "Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin)".
6. Hieda Y, Tsukita S, Tsukita S (Oct 1989). "A new high molecular mass protein showing unique localization in desmosomal plaque.". J Cell Biol. 109 (4): 1511–1518. doi:10.1083/jcb.109.4.1511. PMC 2115823. PMID 2677021.
7. Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR (May 2010). "Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells.". Cancer Res. 70 (9): 3780–3790. doi:10.1158/0008-5472.CAN-09-4439. PMID 20388789.
8. Gentil, B J; Delphin C; Mbele G O; Deloulme J C; Ferro M; Garin J; Baudier J (Jun 2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B". J. Biol. Chem. United States. 276 (26): 23253–61. doi:10.1074/jbc.M010655200. ISSN 0021-9258. PMID 11312263.

External links

• Human AHNAK genome location and AHNAK gene details page in the UCSC Genome Browser.

Further reading

• Shtivelman E, Cohen FE, Bishop JM (1992). "A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure.". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5472–6. doi:10.1073/pnas.89.12.5472. PMC 49314. PMID 1608957.
• Kudoh J, Wang Y, Minoshima S, et al. (1995). "Localization of the human AHNAK/desmoyokin gene (AHNAK) to chromosome band 11q12 by somatic cell hybrid analysis and fluorescence in situ hybridization.". Cytogenet. Cell Genet. 70 (3-4): 218–20. doi:10.1159/000134037. PMID 7789175.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Gentil BJ, Delphin C, Mbele GO, et al. (2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B.". J. Biol. Chem. 276 (26): 23253–61. doi:10.1074/jbc.M010655200. PMID 11312263.
• Sussman J, Stokoe D, Ossina N, Shtivelman E (2001). "Protein kinase B phosphorylates AHNAK and regulates its subcellular localization.". J. Cell Biol. 154 (5): 1019–30. doi:10.1083/jcb.200105121. PMC 2196192. PMID 11535620.
• Wernyj RP, Ewing CM, Isaacs WB (2004). "Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery.". Cell Motil. Cytoskeleton. 50 (2): 101–13. doi:10.1002/cm.1044. PMID 11746675.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Straub BK, Boda J, Kuhn C, et al. (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.". J. Cell. Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Haase H, Pagel I, Khalina Y, et al. (2004). "The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.". FASEB J. 18 (7): 839–41. doi:10.1096/fj.03-0446fje. PMID 15001564.
• Lee IH, You JO, Ha KS, et al. (2004). "AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.". J. Biol. Chem. 279 (25): 26645–53. doi:10.1074/jbc.M311525200. PMID 15033986.
• Stiff T, Shtivelman E, Jeggo P, Kysela B (2004). "AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation.". DNA Repair (Amst.). 3 (3): 245–56. doi:10.1016/j.dnarep.2003.11.001. PMID 15177040.
• Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.
• Haase H, Alvarez J, Petzhold D, et al. (2006). "Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.". FASEB J. 19 (14): 1969–77. doi:10.1096/fj.05-3997com. PMID 16319140.
• Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening.". Cell Cycle. 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.
• De Seranno S, Benaud C, Assard N, et al. (2007). "Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer.". J. Biol. Chem. 281 (46): 35030–8. doi:10.1074/jbc.M606545200. PMID 16984913.