APIP

APIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M6R
Identifiers
Aliases	APIP, APIP2, CGI29, MMRP19, hCGI-29, APAF1 interacting protein
External IDs	MGI: 1926788 HomoloGene: 6277 GeneCards: APIP
Gene ontology Molecular function • protein binding • metal ion binding • lyase activity • identical protein binding • zinc ion binding • methylthioribulose 1-phosphate dehydratase activity Cellular component • cytoplasm Biological process • methionine biosynthetic process • L-methionine biosynthetic process from S-adenosylmethionine • negative regulation of apoptotic process • cellular amino acid biosynthetic process • regulation of ERK1 and ERK2 cascade • apoptotic process • pyroptosis • protein homotetramerization • L-methionine biosynthetic process from methylthioadenosine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51074	56369
Ensembl	ENSG00000149089	ENSMUSG00000010911
UniProt	Q96GX9	Q9WVQ5
RefSeq (mRNA)	NM_015957	NM_019735
RefSeq (protein)	NP_057041.2	NP_062709.3
Location (UCSC)	Chr 11: 34.85 – 34.92 Mb	Chr 2: 103.07 – 103.09 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene.^[3][4][5] It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity^[6][7] which is involved in the methionine salvage pathway.

APIP deficiency is associated with cell death^[8] and cancer.

Interactions

APIP has been shown to interact with APAF1.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
4. Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (Sep 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein". J Biol Chem. 279 (38): 39942–50. doi:10.1074/jbc.M405747200. PMID 15262985.
5. "Entrez Gene: APIP APAF1 interacting protein".
6. Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L (2012). Di Cunto F, ed. "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway". PLoS ONE. 7 (12): e52877. doi:10.1371/journal.pone.0052877. PMC 3532061. PMID 23285211.
7. Kang, W; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le Le, T. M.; Lim, B; Kim, H. C.; Kim, T. Y.; Ashida, H; Yokota, A; Hah, S. S.; Chun, K. H.; Jung, Y. K.; Yang, J. K. (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences. 111 (1): E54–61. doi:10.1073/pnas.1308768111. PMC 3890807. PMID 24367089.
8. Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death". Proceedings of the National Academy of Sciences. 109 (35): E2343–E2352. doi:10.1073/pnas.1206701109. PMC 3435171. PMID 22837397.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.