APOL2

APOL2
Identifiers
Aliases	APOL2, APOL-II, APOL3, apolipoprotein L2
External IDs	MGI: 2444921 HomoloGene: 12785 GeneCards: APOL2
Genetically Related Diseases
schizophrenia[1]
Gene ontology Molecular function • receptor binding • lipid binding • high-density lipoprotein particle binding Cellular component • cytoplasm • extracellular region • endoplasmic reticulum membrane • membrane Biological process • multicellular organism development • lipoprotein metabolic process • transport • lipid transport • cholesterol metabolic process • acute-phase response • maternal process involved in female pregnancy • lipid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23780	239552
Ensembl	ENSG00000128335	ENSMUSG00000056656
UniProt	Q9BQE5	n/a
RefSeq (mRNA)	NM_030882 NM_145637	NM_001081970
RefSeq (protein)	NP_112092.2 NP_663612.2	n/a
Location (UCSC)	Chr 22: 36.23 – 36.24 Mb	Chr 15: 77.75 – 77.76 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene.^[4][5][6]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.^[6]

References

1. "Diseases that are genetically associated with APOL2 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
5. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
6. "Entrez Gene: APOL2 apolipoprotein L, 2".

Further reading

• McGhee KA, Morris DW, Schwaiger S (2005). "Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs". Schizophr. Res. 76 (2–3): 231–8. doi:10.1016/j.schres.2005.01.006. PMID 15949655.
• Gerhard DS, Wagner L, Feingold EA (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue". Genomics. 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
• Duchateau PN, Pullinger CR, Cho MH (2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". J. Lipid Res. 42 (4): 620–30. PMID 11290834.
• Adams MD, Kerlavage AR, Fleischmann RD (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.