ARHGAP9

ARHGAP9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2P0D, 2P0H
Identifiers
Aliases	ARHGAP9, 10C, RGL1, Rho GTPase activating protein 9
External IDs	MGI: 2143764 HomoloGene: 13041 GeneCards: ARHGAP9
Gene ontology Molecular function • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • lipid binding • GTPase activator activity Cellular component • cytosol Biological process • regulation of small GTPase mediated signal transduction • signal transduction • positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64333	216445
Ensembl	ENSG00000123329	ENSMUSG00000040345
UniProt	Q9BRR9	n/a
RefSeq (mRNA)	NM_001080156 NM_001080157 NM_032496 NM_001319850 NM_001319851 NM_001319852	NM_001285785 NM_146011
RefSeq (protein)	NP_001073625.1 NP_001073626.1 NP_115885.2 NP_001306779.1 NP_001306780.1 NP_001306781.1 NP_001306779.1	n/a
Location (UCSC)	Chr 12: 57.47 – 57.49 Mb	Chr 10: 127.32 – 127.33 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.^[3][4]

Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.
4. "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

Further reading

• Peck J, Douglas G, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Letters. 528 (1-3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.