ARHGEF10

ARHGEF10
Identifiers
Aliases	ARHGEF10, GEF10, SNCV, Rho guanine nucleotide exchange factor 10
External IDs	MGI: 2444453 HomoloGene: 22827 GeneCards: ARHGEF10
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • protein binding • kinesin binding • guanyl-nucleotide exchange factor activity Cellular component • cytosol • centrosome Biological process • mitotic spindle assembly • regulation of Rho protein signal transduction • positive regulation of stress fiber assembly • myelination in peripheral nervous system • centrosome duplication • activation of GTPase activity • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9639	234094
Ensembl	n/a	ENSMUSG00000071176
UniProt	O15013	Q8C033
RefSeq (mRNA)	NM_001308152 NM_001308153 NM_014629	NM_001037736 NM_172751
RefSeq (protein)	NP_001295081.1 NP_001295082.1 NP_055444.2	NP_001032825.1 NP_766339.2
Location (UCSC)	Chr 8: 1.82 – 1.96 Mb	Chr 8: 14.91 – 15 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.^[3][4][5]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
4. Mohl M, Winkler S, Wieland T, Lutz S (Aug 2006). "Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture". Naunyn Schmiedebergs Arch Pharmacol. 373 (5): 333–41. doi:10.1007/s00210-006-0083-0. PMID 16896804.
5. "Entrez Gene: ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Jungerius BJ, Hoogendoorn ML, Bakker SC, et al. (2008). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia". Molecular Psychiatry. 13 (11): 1060–8. doi:10.1038/sj.mp.4002080. PMID 17893707.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Verhoeven K, De Jonghe P, Van de Putte T, et al. (2003). "Slowed Conduction and Thin Myelination of Peripheral Nerves Associated with Mutant Rho Guanine-Nucleotide Exchange Factor 10". Am. J. Hum. Genet. 73 (4): 926–32. doi:10.1086/378159. PMC 1180612. PMID 14508709.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ranta S, Lehesjoki AE, de Fatima Bonaldo M, et al. (1997). "High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p". Genome Res. 7 (9): 887–96. doi:10.1101/gr.7.9.887. PMID 9314494.