ATF/CREB

The ATF/CREB family is a group of transcription factors, consisting of different ATFs (Activating transcription factors), CREB (cAMP response element binding protein), CREM (cAMP response element modulator) and related proteins.[1][2] Among the transcription factors assigned to this group, some are more related to CREB-like, factors, whereas other exhibit closer similarity with the AP-1 transcription factor components c-Jun or c-Fos.[3]

Common features are a basic leucine zipper type of DNA-binding domain and binding as a dimer to DNA sequences like 5'-TGACGTCA-3' or 5'-TGA(C/G)TCA-3' as recognition sequences.[4]

References

  1. ↑ Targeted mutation of the CREB gene: Compensation within the CREB/ATF family of transcription factors EDITH HUMMLER, TIMOTHY J. COLE, JULIE A. BLENDY, RUTH GANSS, ADRIANO AGUZZII, WOLFGANG SCHMID, FRIEDRICH BEERMANN, AND GÜNTHER SCHÜTZ Proc. Nati. Acad. Sci. USA. Vol. 91, pp. 5647-5651, June 1994, Biochemistry
  2. ↑ Karin M1, Smeal T (1992). "Control of transcription factors by signal transduction pathways: the beginning of the end". Trends Biochem Sci. 17 (10): 418–22. doi:10.1016/0968-0004(92)90012-x. PMID 1455510.
  3. ↑ "Classification of Human Transcription Factors (TFClass)".
  4. ↑ Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. pp. 125–126. ISBN 1-4160-2328-3.
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