AURKC

AURKC
Identifiers
Aliases	AURKC, AIE2, AIK3, ARK3, AurC, SPGF5, STK13, aurora-C, HEL-S-90, aurora kinase C
External IDs	MGI: 1321119 HomoloGene: 68302 GeneCards: AURKC
Targeted by Drug
SU6656, tozasertib[1]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • histone serine kinase activity • kinase activity • protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • ATP binding Cellular component • cytoplasm • condensed nuclear chromosome, centromeric region • spindle • spindle pole centrosome • chromosome • chromosome passenger complex • midbody • spindle microtubule • spindle midzone • chromosome, centromeric region • cytoskeleton • condensed chromosome • nucleus Biological process • mitotic nuclear division • phosphorylation • mitotic spindle midzone assembly • histone modification • cytokinesis • oocyte development • positive regulation of cytokinesis • cell division • protein phosphorylation • meiotic cell cycle • spindle midzone assembly • spermatogenesis • cell cycle • attachment of spindle microtubules to kinetochore • histone-serine phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6795	20871
Ensembl	ENSG00000105146	ENSMUSG00000070837
UniProt	Q9UQB9	O88445
RefSeq (mRNA)	NM_001015878 NM_001015879 NM_003160	NM_001080965 NM_001080966 NM_020572
RefSeq (protein)	NP_001015878.1 NP_001015879.1 NP_003151.2	XP_011236344.1 XP_011236345.1 XP_011236346.1 XP_011236347.1 XP_011236348.1
Location (UCSC)	Chr 19: 57.23 – 57.24 Mb	Chr 7: 7 – 7 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene.^[4][5]

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.^[5]

References

1. "Drugs that physically interact with Aurora kinase C view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Bernard M, Sanseau P, Henry C, Couturier A, Prigent C (Dec 1998). "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter". Genomics. 53 (3): 406–9. doi:10.1006/geno.1998.5522. PMID 9799611.
5. "Entrez Gene: AURKC aurora kinase C".

Further reading

• Katayama H, Brinkley WR, Sen S (2004). "The Aurora kinases: role in cell transformation and tumorigenesis.". Cancer Metastasis Rev. 22 (4): 451–64. doi:10.1023/A:1023789416385. PMID 12884918.
• Tseng TC, Chen SH, Hsu YP, Tang TK (1998). "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators.". DNA Cell Biol. 17 (10): 823–33. doi:10.1089/dna.1998.17.823. PMID 9809744.
• Kimura M, Matsuda Y, Yoshioka T, Okano Y (1999). "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3.". J. Biol. Chem. 274 (11): 7334–40. doi:10.1074/jbc.274.11.7334. PMID 10066797.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Li X, Sakashita G, Matsuzaki H, et al. (2004). "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.". J. Biol. Chem. 279 (45): 47201–11. doi:10.1074/jbc.M403029200. PMID 15316025.
• Sasai K, Katayama H, Stenoien DL, et al. (2005). "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.". Cell Motil. Cytoskeleton. 59 (4): 249–63. doi:10.1002/cm.20039. PMID 15499654.
• Yan X, Wu Y, Li Q, et al. (2005). "Cloning and characterization of a novel human Aurora C splicing variant.". Biochem. Biophys. Res. Commun. 328 (1): 353–61. doi:10.1016/j.bbrc.2004.12.168. PMID 15670791.
• Chen HL, Tang CJ, Chen CY, Tang TK (2005). "Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy.". J. Biomed. Sci. 12 (2): 297–310. doi:10.1007/s11373-005-0980-0. PMID 15917996.
• Yan X, Cao L, Li Q, et al. (2005). "Aurora C is directly associated with Survivin and required for cytokinesis.". Genes Cells. 10 (6): 617–26. doi:10.1111/j.1365-2443.2005.00863.x. PMID 15938719.
• Dutertre S, Hamard-Péron E, Cremet JY, et al. (2006). "The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression.". Cell Cycle. 4 (12): 1783–7. doi:10.4161/cc.4.12.2172. PMID 16258285.
• Dieterich K, Soto Rifo R, Faure AK, et al. (2007). "Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.". Nat. Genet. 39 (5): 661–5. doi:10.1038/ng2027. PMID 17435757.