RRNA endonuclease

RRNA endonuclease
Identifiers
EC number 3.1.27.10
CAS number 1407-48-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

RRNA endonuclease (EC 3.1.27.10, alpha-sarcin) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes

This enzyme also acts on bacterial rRNA.

References

  1. Endo, Y.; Tsurugi, K. (1988). "The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA". J. Biol. Chem. 263 (18): 8735–8739. PMID 3288622.
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