Amikhelline

Amikhelline
Clinical data
ATC code none
Pharmacokinetic data
Metabolism none
Identifiers
CAS Number 4439-67-2 YesY
PubChem (CID) 71198
ChemSpider 64334 YesY
UNII BD9T227F6M YesY
ChEMBL CHEMBL2104025
Chemical and physical data
Formula C18H21NO5
Molar mass 331.363 g/mol
3D model (Jmol) Interactive image
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Amikhelline is an antimitotic drug.[1] It acts as a DNA intercalator[2] and inhibits DNA polymerase.[3]

References

  1. Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP. Characterization of chromosomal aberrations induced in man by various antimitotic agents. (French). Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales. 1985;179(3):331-9. PMID 2417673
  2. Rucheton M, Jeanteur P. Studies on amikhellin. I. Intercalative binding to double-stranded DNA. Biochimie. 1973;55(11):1415-20. PMID 4364376
  3. Rucheton M, Jeanteur P. Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus. Biochimie. 1976;58(6):689-95. PMID 60141



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