Anti-LKM antibody
Anti-Liver Kidney Microsomal Antibodies (Anti-LKM antibody) are detected in the serum of patients with different types of acute or chronic liver disease. These antibodies are targeted against cytochrome P450 antigens. There are three kinds of Anti- Liver Kidney Microsomal Antibodies
| Microsomal Antibodies | Antigen | Disease |
|---|---|---|
| Anti-LKM 1 | Cytochrome P450 2D6 | Autoimmune hepatitis type II and Chronic Hepatitis C(10%) |
| Anti-LKM 2 | Cytochrome P450 2C9 | Drug-induced hepatitis (Tienilic acid induced) |
| Anti-LKM 3 | Cytochrome P450 1A2 | Chronic active hepatitis in association with Autoimmune Polyendocrine Syndrome type 1;[1] Hepatitis D |
References
- ↑ Gebre-Medhin G et al., FEBS Letters 1997
This article is issued from Wikipedia - version of the 11/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.