Armin Kutzsche

Dr. Armin Kutzsche
Born (1914-02-17)17 February 1914[1]
Frankfurt am Main
Died 19 February 1995(1995-02-19) (aged 81)
Frankfurt am Main
Nationality German
Fields Medical microbiology
Institutions
Alma mater
Doctoral advisor Bernhard Fischer-Wasels
Other academic advisors

Armin Karl Wilhelm (A.K.W.) Kutzsche (17 February 1914 – 19 February 1995) was a German physician, microbiologist and industrial scientist. He was a researcher at the universities of Freiburg and Frankfurt, and at the pharmaceutical companies Cassella, Schering and Merck. At Cassella and Schering, he was head of microbiological research and development in the 1950s and 1960s.

Career

He studied medicine at the Goethe University Frankfurt and the University of Freiburg, and graduated in 1937. He obtained his doctorate in 1939,[2] with a dissertation on the influence on tumor grafts by lipoid tumors, supervised by Bernhard Fischer-Wasels,[3] and later became a specialist in internal medicine.[1][2] Early in his career, he was a resident at the Paul Ehrlich Institute and various hospitals, was drafted as a military physician (captain) in the Army Medical Service, and worked as a bacteriologist at Uhlenhuth's research laboratory at the University of Freiburg. He was an assistant professor in Schlossberger's research group at the Institute for Medical Microbiology and Infection Control at the Goethe University Frankfurt 1945–1949.

From 1949 to 1959 he was director of the Microbiological Laboratory of Cassella Farbwerke Mainkur Aktiengesellschaft Cassella (now Sanofi) in Frankfurt, and had a key role in rebuilding Cassella's pharmaceutical research.[1] He was director of the Department of Medical Microbiology at Schering (now Bayer) in West Berlin 1959–1965, and held a secondary appointment at the Research Department of Electron Microscopy at the Free University of Berlin. From 1965 to 1968 he was a principal scientist at the Merck Microbiological Laboratory in Darmstadt. He was chief physician at the Flehe Geriatric Clinic in Düsseldorf 1968–1970, and was a general practitioner and chirotherapist in Offenbach am Main 1970–1984.[2]

Research and scholarship

His scientific work focused on bacteriology, and antibacterial agents in particular, e.g. sulfonamide-based and steroid antibacterials. He has published papers in Medical Microbiology and Immunology, Immunobiology, Drug Research, Cell and Tissue Research, Chemotherapy, Microbiological Research, Antibiotics and Chemotherapy, Clinical Laboratory, Naturwissenschaften, the Journal of Molecular Medicine, and other journals.

He was a co-inventor of several patents held by German pharmaceutical companies, notably of bacteria-inhibiting steroids, with Emanuel Kaspar et al., and 3-methyl-5-isopropylphenyl esters of n-pyrrolidino and n-morpholino carboxylic acids, with Mahmoud Muftić and Horst Peissker. He was also a contributor to the 1952 edition of the book Experimental Bacteriology. He was a member of the editorial boards of the medical journals Internal Medicine (from 1948), Microbiological Research (from 1949) and Physiology, Physiological Chemistry, Pharmacology (from 1956). He was a member of the German Society for Hygiene and Microbiology, of the Senckenberg Nature Research Society, and of the Schopenhauer Society.[2][4]

Scientific publications

  • Kutzsche A (1938). Über die Beeinflussung von Transplantattumoren durch Tumorlipoide [On the influence on tumor grafts by lipoid tumors]. Gelnhausen, F. W. Kalbfleisch. Medical dissertation, 3 March 1939 (Diss. 1939/2626 Univ. Frankfurt).
  • Kutzsche A (1949). Beeinflussung von Transplantattumoren durch Tumorlipoide [Influence on tumor grafts by lipoid tumors]. Zeitschrift für Hygiene und Infectionskrankheiten (= Medical Microbiology and Immunology), 129 (3–4): 278–287. doi:10.1007/BF02184366.
  • Kutzsche A (1949). Ätiologie und Immunotherapie der Experimentaltumoren [Aetiology and immunotherapy of experimental tumors]. Medizinische Monatsschrift, 3: 493–498. PMID 18147888.
  • Kutzsche, A (1950). Epidemiologische Studien über Morbus Weil [Epidemiological studies of Weil's Disease]. Zeitschrift für Immunitätsforschung (= Immunobiology), 107: 257–266.
  • Contributor to Kolle W, Hetsch H, Schlossberger H (eds.) (1952), Experimentelle Bakteriologie und Infektionskrankheiten (= Experimental Bacteriology), Munich, Urban & Schwarzenberg.
  • Kutzsche A (1956). Chirurgische Faeden [Surgical threads]. Patent DE 943009 .
  • Stachel A, Kutzsche A, Zerweck W (1957). Nu-nu-dibenzylsulfamyl benzoic acid. U.S. Patent 2,805,250.
  • Trösken O, Hintermeier K, Kutzsche A (1959). Verfahren zur Herstellung von therapeutisch wertvollen Sulfobernsteinsaeureamiden [Process for the preparation of therapeutically valuable sulfobernstein acid amides]. Patent DE 1055523 .
  • Knott T, Walter AM, Kutzsche A (1961). Antibakterielle Wirksamkeit des 2-Sulfanilamido-5-methoxy-pyrimidins [Antibacterial effectiveness of 2-sulfanilamido-5-methoxy-pyrimidine]. Arzneimittelforschung (= Drug Research), 11: 684–694. PMID 14457340.
  • Schwarz W, Merker HJ, Kutzsche A (1962). Elektronenmikroskopische Untersuchungen über die Fibrillogenese in Fibroblastenkulturen [Electron microscopic studies on fibrillogenesis in fibroblast cultures]. Zeitschrift für Zellforschung und Mikroskopische Anatomie (= Cell and Tissue Research), 56 (1): 107–124. doi:10.1007/BF00326850. PMID 13909788.
  • Kutzsche A (1962). Die minimale Hemmkonzentration von Sulfanilamiden [The Minimum Inhibitory Concentration of Sulfanilamides]. Das Ärztliche Laboratorium: Zeitschrift für den Laboratoriumsarzt und die ärztliche Praxis (= Clinical Laboratory), 8: 330–332.
  • Knott T, Walter AM, Kutzsche A (1962). Die Bestimmung der in-vitro-Empfindlichkeit von Bakterien gegen Durenat [The determination of the in vitro susceptibility of bacteria to Durenat]. Medizinische Mitteilungen 23: 14.
  • Schwarz W, Merker HJ, Kutzsche A (1964). Elektronenmikroskopische Untersuchungen an verfetteten Fibroblastenkulturen nach verzögerter Umsetzung [Electron microscopic studies on fibroblast cultures having undergone fatty degeneration after retarded double decomposition]. Zeitschrift fur Zellforschung und Mikroskopische Anatomie (= Cell and Tissue Research) 64: 804–812. doi:10.1007/BF00323311. PMID 14338283.
  • Kutzsche A (1964). Einige mikrobiologische Besonderheiten neuerer Sulfanilamide [Some microbiological characteristics of newer Sulfanilamides]. Chemotherapia (= Chemotherapy) 8: 53–62. doi:10.1159/000220295. PMID 14178045.
  • Kutzsche A (1964). Die Färbung der Tuberkelbakterien [Staining of tubercle bacteria]. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (= Microbiological Research), 194 (2): 252–254. PMID 4157876.
  • Kutzsche A (1964). Die Bedeutung der in vitro-Teste für die klinische Prüfung von Chemotherapeutica [The importance of in vitro tests for the clinical testing of chemotherapeutic agents]. Antibiot. Chemother. Fortschr. (Basel) (= Antibiotics and Chemotherapy), 12: 315–333. doi:10.1159/000386745. PMID 14262399.
  • Kutzsche A (1964). Vorkommen und Verteilung der Tuberkelbakterien während des Ablaufes der Lungentuberkulose und ihr färberischer Nachweis mit Viktoriablau 4 R [Occurrence and distribution of tubercle bacilli during the course of pulmonary tuberculosis and its demonstration by staining with Victoria blue 4 R]. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (= Microbiological Research), 193 (2): 196–199. PMID 4157612.
  • Kutzsche A (1964). The Minimum Inhibitory Concentration of Sulfanilamides under Different Test Conditions. In Robert-Henri Regamey (ed.), Progress in Immunobiological Standardization, 1: 48–51.
  • Kutzsche A (1964). Le problème des germes endommagés [The problem of damaged germs]. In Robert-Henri Regamey (ed.), Progress in Immunobiological Standardization, 1: 213.
  • Kutzsche A (1965). Zur Toxikologie des Dimethylformamids [On the toxicology of dimethylformamide]. Arzneimittelforschung (= Drug Research), 15 (6): 618–624. PMID 5899239.
  • Kutzsche A (1965). Beitrag zur Diagnostik der Tuberkelbakterien [On the diagnosis of tubercle bacteria]. Das Ärztliche Laboratorium: Zeitschrift für den Laboratoriumsarzt und die ärztliche Praxis (= Clinical Laboratory), 11: 4–10.
  • Kutzsche A, Merker HJ, Schwarz W (1965). Morphologische Beobachtungen über die Sulfanilamideinwirkung auf Fibroblastenkulturen [Morphological observations on the influence of sulfanilamide on fibroblast cultures]. Naturwissenschaften, 52 (5): 118. doi:10.1007/BF00626341.
  • Gerhards E, Gibian H, Kutzsche, A (1965). Sulfonamidausscheidung und bacteriostatische Aktivität im Harn nach oraler Verabreichung des Langzeitsulfonamids 2-Sulfanilamido-5-methoxypyrimidin (Sulfamethoxydiazin) und des Kurzzeitsulfonamids N-Sulfanilylcarbamid [Sulfonamide excretion and bacteriostatic activity in urine after oral administration of the long-term sulfonamide 2-sulfanilamido-5-methoxy-pyrimidine (sulfamethoxydiazine) and the short-term sulfonamide N-sulfanilylcarbamide]. Arzneimittelforschung (= Drug Research), 15: 512–516. PMID 5898292.
  • Schwarz W, Kutzsche A (1966). Elektronenmikroskopische Untersuchungen über die anabole und katabole Wirkung von Dexamethason und Methenolonester auf Fibroblasten in vitro [Electron microscopic studies on the anabolic and catabolic effects of dexamethasone and methenolonester on fibroblasts in vitro]. Klinische Wochenschrift (= Journal of Molecular Medicine), 44 (16): 979–982. doi:10.1007/BF01711473. PMID 4871120.
  • Kutzsche A, Vöge HO (1966). Zur Verträglichkeit einer Gentamycin-Creme [The compatibility of a Gentamicin cream]. Arzneimittelforschung (= Drug Research), 16 (1): 11–14. PMID 6013749.
  • Kutzsche A (1966). Vergleich verschiedener Methoden zur Prüfung von Desinfektionsmitteln [Comparison of different methods for testing disinfectants]. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (= Microbiological Research), 201: 318.
  • Kaspar E, Hempel G, Philippson R, Kutzsche A (1968). Bacteria-inhibiting steroids and method of making the same. U.S. Patent 3,415,817.
  • Kutzsche A, Muftić MK, Peissker H (1969). 3-methyl-5-isopropylphenyl esters of n-pyrrolidino and n-morpholino carboxylic acids. U.S. Patent 3,457,262.

References

  1. 1 2 3 Oestreich, Gerhard, ed. (1954). "Kutzsche, Armin". Kürschners Deutscher Gelehrten-Kalender: Lexikon der lebenden deutschsprachigen Wissenschaftler (8 ed.). Walter de Gruyter. p. 684.
  2. 1 2 3 4 Schuder, Werner, ed. (1961). "Kutzsche, Armin". Kürschners Deutscher Gelehrten-Kalender. 1 (9 ed.). Walter de Gruyter. p. 1132.
  3. ↑ Über die Beeinflussung von Transplantattumoren durch Tumorlipoide, stabikat.de
  4. ↑ Schopenhauer-Jahrbuch, 1987, p. 297, Verlag Valdemar Kramer
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