Unspecific peroxygenase

Unspecific peroxygenase
Identifiers
EC number	1.11.2.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Unspecific peroxygenase (EC 1.11.2.1, aromatic peroxygenase, mushroom peroxygenase, haloperoxidase-peroxygenase, Agrocybe aegerita peroxidase) is an enzyme with systematic name substrate:hydrogen peroxide oxidoreductase (RH-hydroxylating or -epoxidising).^{[1][2][3][4][5][6][7][8][9]} This enzyme catalyses the following chemical reaction

RH + H₂O₂ $\rightleftharpoons$ ROH + H₂O

Unspecific peroxygenase is a heme-thiolate protein comparable to Cytochrome_P450 in the ability to catalyze a variety of P450 reactions (hence "unspecific"), but forms a unique, solely fungal, protein family of extracellular enzymes.

References

1. Ullrich, R.; Nuske, J.; Scheibner, K.; Spantzel, J.; Hofrichter, M. (2004). "Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes". Appl. Environ. Microbiol. 70 (8): 4575–4581. doi:10.1128/AEM.70.8.4575-4581.2004. PMC 492325. PMID 15294788.
2. Ullrich, R.; Hofrichter, M. (2005). "The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene". FEBS Lett. 579 (27): 6247–6250. doi:10.1016/j.febslet.2005.10.014. PMID 16253244.
3. Anh, D.H.; Ullrich, R.; Benndorf, D.; Svatos, A.; Muck, A.; Hofrichter, M. (2007). "The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation". Appl. Environ. Microbiol. 73 (17): 5477–5485. doi:10.1128/AEM.00026-07. PMC 2042081. PMID 17601809.
4. Ullrich, R.; Dolge, C.; Kluge, M.; Hofrichter, M. (2008). "Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita". FEBS Lett. 582 (29): 4100–4106. doi:10.1016/j.febslet.2008.11.006. PMID 19022254.
5. Aranda, E.; Kinne, M.; Kluge, M.; Ullrich, R.; Hofrichter, M. (2009). "Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases". Appl. Microbiol. Biotechnol. 82 (6): 1057–1066. doi:10.1007/s00253-008-1778-6. PMID 19039585.
6. Kinne, M.; Poraj-Kobielska, M.; Aranda, E.; Ullrich, R.; Hammel, K.E.; Scheibner, K.; Hofrichter, M. (2009). "Regioselective preparation of 5-hydroxypropranolol and 4′-hydroxydiclofenac with a fungal peroxygenase". Bioorg. Med. Chem. Lett. 19 (11): 3085–3087. doi:10.1016/j.bmcl.2009.04.015. PMID 19394224.
7. Kluge, M.; Ullrich, R.; Dolge, C.; Scheibner, K.; Hofrichter, M. (2009). "Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H₂O₂ and intermediary epoxidation". Appl. Microbiol. Biotechnol. 81 (6): 1071–1076. doi:10.1007/s00253-008-1704-y. PMID 18815784.
8. Kinne, M.; Poraj-Kobielska, M.; Ralph, S.A.; Ullrich, R.; Hofrichter, M.; Hammel, K.E. (2009). "Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase". J. Biol. Chem. 284: 29343–29349. doi:10.1074/jbc.M109.040857. PMC 2785565. PMID 19713216.
9. Pecyna, M.J.; Ullrich, R.; Bittner, B.; Clemens, A.; Scheibner, K.; Schubert, R.; Hofrichter, M. (2009). "Molecular characterization of aromatic peroxygenase from Agrocybe aegerita". Appl. Microbiol. Biotechnol. 84 (5): 885–897. doi:10.1007/s00253-009-2000-1. PMID 19434406.

External links