Aspidophytine
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| Identifiers | |
|---|---|
16625-21-1  | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 9958575 |
| PubChem | 11783895 |
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| Properties | |
| C22H26N2O4 | |
| Molar mass | 382.45 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Aspidophytine is an indole alkaloid that has attracted a lot of attention from synthetic chemists.[1][2][3][4] An extract of the cockroach plant, aspidophytine is an insecticidal substance particularly effective against cockroaches. It is one of the two components of the dimer haplophytine.[5]
In his suicide note, Harvard doctoral student Jason Altom mentioned his stress in attempting to devise a synthetic pathway for the aspidophytine sub-unit of haplophytine as a contributing factor to his psychological breakdown.[6]
References
- ↑ "Enantioselective Total Synthesis of Aspidophytine" He, F.; Bo, Y.; Altom, J. D.; Corey, E. J. J. Am. Chem. Soc. 1999, 121(28), 6771–6772 (doi:10.1021/ja9915201)
- ↑ "Stereocontrolled total synthesis of (−)-aspidophytine" Sumi, S.; Matsumoto, K.; Tokuyama, H.; Fukuyama, T. Tetrahedron 2003, 59, 8571–8587 (doi:10.1016/j.tet.2003.09.005)
- ↑ "Application of the Rh(II) Cyclization/Cycloaddition Cascade for the Total Synthesis of (±)-Aspidophytine" Mejia-Oneto, J. M., Padwa, A. Org. Lett. 2006, 8, 3275–3278 (doi:10.1021/ol061137i)
- ↑ "A Concise Asymmetric Total Synthesis of Aspidophytine" Nicolaou, K. C., Dalby, S. M., Majumder, U. J. Am. Chem. Soc. 2008, 130(45), 14942–14943 (doi:10.1021/ja806176w)
- ↑ Column: Totally Synthetic, by Paul Docherty, at the Royal Society of Chemistry; published October 9, 2009; retrieved October 3, 2014
- ↑ Lethal Chemistry at Harvard, by Stephen S> Hall, in the New York Times; published November 29, 1998; retrieved October 3, 2014
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