Auxilin

DNAJC6
Identifiers
Aliases DNAJC6, DJC6, PARK19, Auxilin, DnaJ heat shock protein family (Hsp40) member C6
External IDs MGI: 1919935 HomoloGene: 8865 GeneCards: DNAJC6
Orthologs
Species Human Mouse
Entrez

9829

72685

Ensembl

ENSG00000116675

ENSMUSG00000028528

UniProt

O75061

Q80TZ3

RefSeq (mRNA)

NM_001256864
NM_001256865
NM_014787

NM_001164583
NM_001164584
NM_001164585
NM_198412

RefSeq (protein)

NP_001243793.1
NP_001243794.1
NP_055602.1

NP_001158055.1
NP_001158056.1
NP_001158057.1
NP_940804.1

Location (UCSC) Chr 1: 65.25 – 65.42 Mb Chr 4: 101.5 – 101.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.[3][4][5]

Function

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).[5]

Structure

The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Oct 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
  4. Ohtsuka K, Hata M (Apr 2000). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. PMC 312896Freely accessible. PMID 11147971.
  5. 1 2 "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6".
  6. Haynie DT, Xue B (Feb 2015). "Superdomains in the protein structure hierarchy: The case of PTP-C2". Protein Science. 24: 874–82. doi:10.1002/pro.2664. PMC 4420535Freely accessible. PMID 25694109.

Further reading

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