Azoximer bromide

Azoximer bromide
Clinical data
ATC code L03AX (WHO)
Pharmacokinetic data
Bioavailability up to 89%
Biological half-life 25.4 hours (intravenous routes)
Identifiers
Synonyms Polyoxidonium, Synpol
CAS Number 892497-01-7
ChemSpider none
Chemical and physical data
Formula [[C8H15BrN2O2]x[C6H12N2O]y]n
Molar mass 60000–100000 g/mol

Azoximer bromide is a macromolecular compound with high-molecular weight and high immunomodulating activity. It is used in Russia and CIS in treatment and prophylaxis of diseases connected with damage of immune system. It is a N-oxidized polyethylene–piperazine derivative.

Azoximer bromide is registered in US Patent-5503830 from 1996,[1][2][3] in the Russian Federation from 1996, under registration number 96/302/9, FS 42-3906-00.[4]

Medical uses

In adults with secondary immunodeficient states as

- relapsing chronic bacterial infections

- relapsing chronic viral infections

- acute bacterial infections

- acute viral infections

- allergic diseases (pollinosis, bronchial asthma, atopic dermatitis)

- severe septic states

- postoperative complications - purulent affections

- when primary treatment develops cellular immunity decrease (cytostatic treatment, X-rays)

References

  1. ↑ http://www.google.com/patents/about?id=s9cfAAAAEBAJ&dq=US+5503830
  2. ↑ http://www.wikipatents.com/US-Patent-5503830/compounds-having-immunostimulating-activity-and-methods-of-use-thereof[]
  3. ↑ http://www.freepatentsonline.com/EP0789586.html
  4. ↑ State Scientific Centre of Russian federation, Immunological Institute of Russian Federation Health Resort, CLINICAL ASPECTS OF USE OF IMMUNOMODULATOR POLYOXIDONIUM, Methodical handbook for doctors issued by State Scientific Centre of Russian Federation – Immunological Institute of Russian Federation Health Resort Moscow – 2003


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