C1D

C1D
Identifiers
Aliases C1D, LRP1, SUN-CoR, SUNCOR, hRrp47, C1D nuclear receptor corepressor
External IDs MGI: 1927354 HomoloGene: 4619 GeneCards: C1D
Orthologs
Species Human Mouse
Entrez

10438

57316

Ensembl

ENSG00000197223

ENSMUSG00000000581

UniProt

Q13901

O35473

RefSeq (mRNA)

NM_173177
NM_001190263
NM_001190265
NM_006333

NM_020558

RefSeq (protein)

NP_001177192.1
NP_001177194.1
NP_006324.1
NP_775269.1

NP_065583.2

Location (UCSC) Chr 2: 68.04 – 68.11 Mb Chr 11: 17.26 – 17.27 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene.[3][4][5][6][7][8]

Function

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.[8]

Interactions

C1D has been shown to interact with TSNAX[9] and DNA-PKcs.[10]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Nehls P, Keck T, Greferath R, Spiess E, Glaser T, Rothbarth K, Stammer H, Werner D (Apr 1998). "cDNA cloning, recombinant expression and characterization of polypetides with exceptional DNA affinity". Nucleic Acids Res. 26 (5): 1160–6. doi:10.1093/nar/26.5.1160. PMC 147382Freely accessible. PMID 9469821.
  4. Schilders G, Egberts WV, Raijmakers R, Pruijn GJ (Jul 2007). "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome". Arthritis Rheum. 56 (7): 2449–54. doi:10.1002/art.22710. PMID 17599775.
  5. Schilders G, van Dijk E, Pruijn GJ (May 2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res. 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMC 1885644Freely accessible. PMID 17412707.
  6. Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.
  7. Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA (Feb 1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. doi:10.1073/pnas.94.26.14400. PMC 24996Freely accessible. PMID 9405624. Check date values in: |year= / |date= mismatch (help)
  8. 1 2 "Entrez Gene: C1D nuclear DNA-binding protein".
  9. Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U (Jan 2002). "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". J. Cell. Sci. 115 (Pt 1): 207–16. PMID 11801738.
  10. Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP (Jul 1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes Dev. 12 (14): 2188–99. doi:10.1101/gad.12.14.2188. PMC 317006Freely accessible. PMID 9679063.

Further reading


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