CDCA5

CDCA5
Identifiers
Aliases CDCA5, SORORIN, cell division cycle associated 5
External IDs MGI: 1915099 HomoloGene: 49860 GeneCards: CDCA5
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

113130

67849

Ensembl

ENSG00000146670

ENSMUSG00000024791

UniProt

Q96FF9

Q9CPY3

RefSeq (mRNA)

NM_080668

NM_026410

RefSeq (protein)

NP_542399.1

NP_080686.1

Location (UCSC) Chr 11: 65.07 – 65.08 Mb Chr 19: 6.08 – 6.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Sororin is a protein that in humans is encoded by the CDCA5 gene.[3][4][5]

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.[6]

Clinical Significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.[7]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  4. Rankin S, Ayad NG, Kirschner MW (Apr 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
  5. "Entrez Gene: CDCA5 cell division cycle associated 5".
  6. Schmitz, J.; Watrin, E.; Lénárt, P.; Mechtler, K.; Peters, JM. (Apr 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.". Curr Biol. 17 (7): 630–6. doi:10.1016/j.cub.2007.02.029. PMID 17349791.
  7. Nguyen, MH.; Koinuma, J.; Ueda, K.; Ito, T.; Tsuchiya, E.; Nakamura, Y.; Daigo, Y. (Jul 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis.". Cancer Res. 70 (13): 5337–47. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

Further reading


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