CENTA2

ADAP2
Identifiers
Aliases	ADAP2, CENTA2, HSA272195, cent-b, ArfGAP with dual PH domains 2
External IDs	MGI: 2663075 HomoloGene: 10179 GeneCards: ADAP2
Gene ontology Molecular function • inositol 1,3,4,5 tetrakisphosphate binding • protein binding, bridging • phosphatidylinositol-4,5-bisphosphate binding • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • metal ion binding • GTPase activator activity • phosphatidylinositol-3,4-bisphosphate binding Cellular component • cytoplasm • plasma membrane • mitochondrial envelope • membrane Biological process • heart development • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55803	216991
Ensembl	ENSG00000184060	ENSMUSG00000020709
UniProt	Q9NPF8	Q8R2V5
RefSeq (mRNA)	NM_018404	NM_172133
RefSeq (protein)	NP_060874.1	NP_742145.1
Location (UCSC)	Chr 17: 30.91 – 30.96 Mb	Chr 11: 80.15 – 80.18 Mb
PubMed search	[1]	[2]
Wikidata

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Arf-GAP with dual PH domain-containing protein 2 is a protein that in humans is encoded by the ADAP2 gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: CENTA2 centaurin, alpha 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Jenne DE, Tinschert S, Stegmann E, et al. (2000). "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions". Genomics. 66 (1): 93–7. doi:10.1006/geno.2000.6179. PMID 10843809.
• Whitley P, Gibbard AM, Koumanov F, et al. (2003). "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle". Eur. J. Cell Biol. 81 (4): 222–30. doi:10.1078/0171-9335-00242. PMID 12018390.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hanck T, Stricker R, Sedehizade F, Reiser G (2004). "Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins". J. Neurochem. 88 (2): 326–36. doi:10.1046/j.1471-4159.2003.02143.x. PMID 14690521.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Venturin M, Bentivegna A, Moroni R, et al. (2005). "Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval". Ann. Hum. Genet. 69 (Pt 5): 508–16. doi:10.1111/j.1529-8817.2005.00203.x. PMID 16138909.
• Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510.