CENTD1

ARAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X40, 2COD
Identifiers
Aliases	ARAP2, CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
External IDs	MGI: 2684416 HomoloGene: 9064 GeneCards: ARAP2
Genetically Related Diseases
amyotrophic lateral sclerosis[1]
Gene ontology Molecular function • phosphatidylinositol-3,4,5-trisphosphate binding • metal ion binding • GTPase activator activity Cellular component • cytoplasm • cytosol Biological process • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	116984	212285
Ensembl	ENSG00000047365	ENSMUSG00000037999
UniProt	Q8WZ64	Q8BZ05
RefSeq (mRNA)	NM_015230 NM_139182	NM_178407
RefSeq (protein)	NP_056045.2	n/a
Location (UCSC)	Chr 4: 35.95 – 36.24 Mb	Chr 5: 62.6 – 62.77 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.^[4]

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene.^[4]

References

1. "Diseases that are genetically associated with ARAP2 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: CENTD1 centaurin, delta 1".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Yoon HY, Miura K, Cuthbert EJ, et al. (2007). "ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP". J. Cell. Sci. 119 (Pt 22): 4650–4666. doi:10.1242/jcs.03237. PMID 17077126.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–731. doi:10.1038/nature03466. PMID 15815621.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Miura K, Jacques KM, Stauffer S, et al. (2002). "ARAP1: a point of convergence for Arf and Rho signaling". Mol. Cell. 9 (1): 109–119. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
• Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–39. doi:10.1093/dnares/5.1.31. PMID 9628581.