CENTD2

ARAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X1V
Identifiers
Aliases	ARAP1, CENTD2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
External IDs	MGI: 1916960 HomoloGene: 12326 GeneCards: ARAP1
Gene ontology Molecular function • type 1 angiotensin receptor binding • metal ion binding • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • GTPase activator activity Cellular component • cytoplasm • cytosol • Golgi apparatus • membrane • plasma membrane • Golgi cisterna membrane • trans-Golgi network • cytoplasmic vesicle Biological process • actin filament reorganization involved in cell cycle • positive regulation of GTPase activity • regulation of cell shape • regulation of cellular component movement • negative regulation of stress fiber assembly • regulation of small GTPase mediated signal transduction • positive regulation of filopodium assembly • signal transduction • positive regulation of receptor recycling • positive regulation of epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116985	69710
Ensembl	ENSG00000186635	ENSMUSG00000032812
UniProt	Q96P48	Q4LDD4
RefSeq (mRNA)	NM_015242 NM_001040118 NM_001135190	NM_001040111 NM_001040112 NM_027180 NM_198096
RefSeq (protein)	NP_001035207.1 NP_001128662.1 NP_056057.2	NP_001035200.1 NP_001035201.1 NP_081456.2 NP_932764.1
Location (UCSC)	Chr 11: 72.69 – 72.79 Mb	Chr 7: 101.35 – 101.41 Mb
PubMed search	[1]	[2]
Wikidata

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Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.^[3]

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: CENTD2 centaurin, delta 2".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol. Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589.
• Miura K, Jacques KM, Stauffer S, et al. (2002). "ARAP1: a point of convergence for Arf and Rho signaling". Mol. Cell. 9 (1): 109–19. doi:10.1016/S1097-2765(02)00428-8. PMID 11804590.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.