COPS8

COPS8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases COPS8, COP9, CSN8, SGN8, COP9 signalosome subunit 8
External IDs MGI: 1915363 HomoloGene: 4882 GeneCards: COPS8
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

10920

108679

Ensembl

ENSG00000198612

ENSMUSG00000034432

UniProt

Q99627

Q8VBV7

RefSeq (mRNA)

NM_198189
NM_006710

NM_133805

RefSeq (protein)

NP_006701.1
NP_937832.1

NP_598566.3

Location (UCSC) Chr 2: 237.09 – 237.1 Mb Chr 1: 90.6 – 90.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.[3][4][5]

The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is related to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Chamovitz DA, Deng XW (Sep 1995). "The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms". Cell. 82 (3): 353–4. doi:10.1016/0092-8674(95)90423-9. PMID 7634324.
  4. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y (May 2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143.
  5. 1 2 "Entrez Gene: COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)".

Further reading


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