CRB3

CRB3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 5I7Z
Identifiers
Aliases	CRB3
External IDs	HomoloGene: 138188 GeneCards: CRB3
Gene ontology Molecular function • SH3 domain binding • protein binding • protein domain specific binding Cellular component • integral component of membrane • cell junction • plasma membrane • apical part of cell • extracellular exosome • apical plasma membrane • membrane • bicellular tight junction • protein complex Biological process • protein localization to plasma membrane • bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	92359	n/a
Ensembl	ENSG00000130545	n/a
UniProt	Q9BUF7	n/a
RefSeq (mRNA)	NM_139161 NM_174881 NM_174882	n/a
RefSeq (protein)	NP_631900.1 NP_777377.1 NP_777378.1	n/a
Location (UCSC)	Chr 19: 6.46 – 6.47 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Crumbs protein homolog 3 is a protein that in humans is encoded by the CRB3 gene.^[2]

Function

This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

References

1. "Human PubMed Reference:".
2. "Entrez Gene: CRB3 crumbs homolog 3 (Drosophila)".

Further reading

• Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (Jul 2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells". The Journal of Biological Chemistry. 277 (28): 25408–15. doi:10.1074/jbc.M202196200. PMID 11964389.
• Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (Jan 2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1-2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
• Roh MH, Fan S, Liu CJ, Margolis B (Jul 2003). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". Journal of Cell Science. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187.
• Lemmers C, Michel D, Lane-Guermonprez L, Delgrossi MH, Médina E, Arsanto JP, Le Bivic A (Mar 2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells". Molecular Biology of the Cell. 15 (3): 1324–33. doi:10.1091/mbc.E03-04-0235. PMC 363137. PMID 14718572.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Fogg VC, Liu CJ, Margolis B (Jul 2005). "Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells". Journal of Cell Science. 118 (Pt 13): 2859–69. doi:10.1242/jcs.02412. PMID 15976445.
• Fan S, Fogg V, Wang Q, Chen XW, Liu CJ, Margolis B (Jul 2007). "A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions". The Journal of Cell Biology. 178 (3): 387–98. doi:10.1083/jcb.200609096. PMC 2064851. PMID 17646395.