CSMD1

CSMD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EHF
Identifiers
Aliases	CSMD1, PPP1R24, CUB and Sushi multiple domains 1
External IDs	MGI: 2137383 HomoloGene: 69536 GeneCards: CSMD1
Genetically Related Diseases
periodontitis, Alzheimer's disease, obesity, schizophrenia, smallpox, coronary artery disease, multiple sclerosis[1]
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64478	94109
Ensembl	ENSG00000183117	ENSMUSG00000060924
UniProt	Q96PZ7	Q923L3
RefSeq (mRNA)	NM_033225	NM_053171
RefSeq (protein)	NP_150094.5	NP_444401.2
Location (UCSC)	Chr 8: 2.94 – 4.99 Mb	Chr 8: 15.89 – 17.54 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

CSMD1 CUB and Sushi multiple domains 1 (Homo sapiens) is a protein that in humans is encoded by the CSMD1 gene.^[4] It is a potential tumour suppressor, the deletion of which may result in head and neck carcinomas behaving more aggressively.

References

1. "Diseases that are genetically associated with CSMD1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: CSMD1 CUB and Sushi multiple domains 1".

Further reading

• Smith DI, Zhu Y, McAvoy S, Kuhn R (2006). "Common fragile sites, extremely large genes, neural development and cancer.". Cancer Lett. 232 (1): 48–57. doi:10.1016/j.canlet.2005.06.049. PMID 16221525.
• Sun PC, Uppaluri R, Schmidt AP, et al. (2001). "Transcript map of the 8p23 putative tumor suppressor region.". Genomics. 75 (1-3): 17–25. doi:10.1006/geno.2001.6587. PMID 11472063.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
• Toomes C, Jackson A, Maguire K, et al. (2003). "The presence of multiple regions of homozygous deletion at the CSMD1 locus in oral squamous cell carcinoma question the role of CSMD1 in head and neck carcinogenesis.". Genes Chromosomes Cancer. 37 (2): 132–40. doi:10.1002/gcc.10191. PMID 12696061.
• Henshall SM, Afar DE, Hiller J, et al. (2003). "Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse.". Cancer Res. 63 (14): 4196–203. PMID 12874026.
• Lau WL, Scholnick SB (2004). "Identification of two new members of the CSMD gene family.". Genomics. 82 (3): 412–5. doi:10.1016/S0888-7543(03)00149-6. PMID 12906867.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Scholnick SB, Richter TM (2003). "The role of CSMD1 in head and neck carcinogenesis.". Genes Chromosomes Cancer. 38 (3): 281–3. doi:10.1002/gcc.10279. PMID 14506705.
• Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Paris PL, Andaya A, Fridlyand J, et al. (2005). "Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors.". Hum. Mol. Genet. 13 (13): 1303–13. doi:10.1093/hmg/ddh155. PMID 15138198.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Richter TM, Tong BD, Scholnick SB (2005). "Epigenetic inactivation and aberrant transcription of CSMD1 in squamous cell carcinoma cell lines.". Cancer Cell Int. 5 (1): 29. doi:10.1186/1475-2867-5-29. PMC 1239921. PMID 16153303.
• Blaveri E, Brewer JL, Roydasgupta R, et al. (2006). "Bladder cancer stage and outcome by array-based comparative genomic hybridization.". Clin. Cancer Res. 11 (19 Pt 1): 7012–22. doi:10.1158/1078-0432.CCR-05-0177. PMID 16203795.
• Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8.". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
• Kraus DM, Elliott GS, Chute H, et al. (2006). "CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues.". J. Immunol. 176 (7): 4419–30. doi:10.4049/jimmunol.176.7.4419. PMID 16547280.