Epi-isozizaene 5-monooxygenase
| Epi-isozizaene 5-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.106 | ||||||||
| CAS number | 1207718-51-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Epi-isozizaene 5-monooxygenase (EC 1.14.13.106, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating).[1] This enzyme catalyses the following chemical reaction
- (+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 O2 albaflavenone + 2 NADP+ + 3 H2O (overall reaction)
- (1a) (+)-epi-isozizaene + NADPH + H+ + O2 (5S)-albaflavenol + NADP+ + H2O
- (1b) (5S)-albaflavenol + NADPH + H+ + O2 albaflavenone + NADP+ + 2 H2O
- (2a) (+)-epi-isozizaene + NADPH + H+ + O2 (5R)-albaflavenol + NADP+ + H2O
- (2b) (5R)-albaflavenol + NADPH + H+ + O2 albaflavenone + NADP+ + 2 H2O
This cytochrome P450 enzyme is purifid from bacterium Streptomyces coelicolor.
References
- ↑ Zhao, B.; Lin, X.; Lei, L.; Lamb, D.C.; Kelly, S.L.; Waterman, M.R.; Cane, D.E. (2008). "Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)". J. Biol. Chem. 283 (13): 8183–8189. doi:10.1074/jbc.M710421200. PMC 2276382
. PMID 18234666.
External links
- Epi-isozizaene 5-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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