Chris O'Brien
Chris O'Brien may refer to:
- Chris O'Brien (American football) (1881–1951), owner of the Chicago Cardinals and co-founder of the National Football League
- Chris O'Brien (baseball) (born 1989), minor league baseball player
- Chris O'Brien (rugby league) (born 1950), Welsh rugby player
- Chris O'Brien (surgeon) (1952–2009), Australian oncologist and surgeon
See also
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