Cytoplasmic polyadenylation element

The cytoplasmic polyadenylation element (CPE) is a sequence element found in the 3' untranslated region of messenger RNA. The most common CPE sequence is UUUUAU, though there are other variations.[1] Binding of CPE binding protein to this region promotes the extension of the existing polyadenine tail and, in general, activation of the mRNA for protein translation. The polyadenine tails are extended from approximately 40 bases to 150 bases.[1] Among other functions, a prominent role for the CPE has been identified in oogenesis and spermatogenesis.[2][3]

References

  1. 1 2 Ivshina, Maria; Lasko, Paul; Richter, Joel D. (11 October 2014). "Cytoplasmic Polyadenylation Element Binding Proteins in Development, Health, and Disease". Annual Review of Cell and Developmental Biology. 30 (1): 393–415. doi:10.1146/annurev-cellbio-101011-155831.
  2. ↑ de Moor, C.H., and Richter, J.D. (1999). Cytoplasmic polyadenylation mediate masking and unmasking of cyclin B1 mRNA. EMBO J. 18, 2294–2303.
  3. ↑ Luitjens C, Gallegos M, Kraemer B, Kimble J, Wickens M. (2000). CPEB proteins control two key steps in spermatogenesis in C. elegans. Genes Dev 14(20):2596-609.
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