DGUOK

DGUOK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OCP
Identifiers
Aliases	DGUOK, deoxyguanosine kinase, MTDPS3, dGK
External IDs	MGI: 1351602 HomoloGene: 8456 GeneCards: DGUOK
Gene ontology Molecular function • transferase activity • nucleotide binding • nucleoside kinase activity • deoxyguanosine kinase activity • kinase activity • ATP binding Cellular component • cytoplasm • cytosol • mitochondrial matrix • mitochondrion • nucleus Biological process • negative regulation of neuron projection development • purine deoxyribonucleoside metabolic process • dGTP metabolic process • phosphorylation • purine-containing compound salvage • guanosine metabolic process • protein phosphorylation • nucleobase-containing compound metabolic process • nucleotide biosynthetic process • deoxyribonucleoside monophosphate biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1716	27369
Ensembl	ENSG00000114956	ENSMUSG00000014554
UniProt	Q16854	Q9QX60
RefSeq (mRNA)	NM_001929 NM_080915 NM_080916 NM_080917 NM_080918 NM_001318859 NM_001318860 NM_001318861 NM_001318862 NM_001318863	NM_001162521 NM_013764
RefSeq (protein)	NP_550438.1 NP_550440.1 NP_001305788.1 NP_001305789.1 NP_001305790.1 NP_001305791.1 NP_001305792.1	NP_038792.2
Location (UCSC)	Chr 2: 73.93 – 73.96 Mb	Chr 6: 83.48 – 83.51 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Deoxyguanosine kinase, mitochondrial is an enzyme that in humans is encoded by the DGUOK gene.^[3]

Function

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: DGUOK deoxyguanosine kinase".

Further reading

• Johansson M, Karlsson A (1996). "Cloning and expression of human deoxyguanosine kinase cDNA". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7258–62. doi:10.1073/pnas.93.14.7258. PMC 38970. PMID 8692979.
• Wang L, Hellman U, Eriksson S (1996). "Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA". FEBS Lett. 390 (1): 39–43. doi:10.1016/0014-5793(96)00623-0. PMID 8706825.
• Johansson M, Bajalica-Lagercrantz S, Lagercrantz J, Karlsson A (1997). "Localization of the human deoxyguanosine kinase gene (DGUOK) to chromosome 2p13". Genomics. 38 (3): 450–1. doi:10.1006/geno.1996.0654. PMID 8975728.
• Jüllig M, Eriksson S (2000). "Mitochondrial and submitochondrial localization of human deoxyguanosine kinase". Eur. J. Biochem. 267 (17): 5466–72. doi:10.1046/j.1432-1327.2000.01607.x. PMID 10951205.
• Jüllig M, Eriksson S (2001). "Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase". J. Biol. Chem. 276 (26): 24000–4. doi:10.1074/jbc.M100435200. PMID 11294860.
• Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
• Johansson K, Ramaswamy S, Ljungcrantz C, Knecht W, Piskur J, Munch-Petersen B, Eriksson S, Eklund H (2001). "Structural basis for substrate specificities of cellular deoxyribonucleoside kinases". Nat. Struct. Biol. 8 (7): 616–20. doi:10.1038/89661. PMID 11427893.
• Mandel H, Szargel R, Labay V, Elpeleg O, Saada A, Shalata A, Anbinder Y, Berkowitz D, Hartman C, Barak M, Eriksson S, Cohen N (2001). "The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA". Nat. Genet. 29 (3): 337–41. doi:10.1038/ng746. PMID 11687800.
• Lotfi K, Månsson E, Peterson C, Eriksson S, Albertioni F (2002). "Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity". Biochem. Biophys. Res. Commun. 293 (5): 1489–96. doi:10.1016/S0006-291X(02)00415-1. PMID 12054684.
• Salviati L, Sacconi S, Mancuso M, Otaegui D, Camaño P, Marina A, Rabinowitz S, Shiffman R, Thompson K, Wilson CM, Feigenbaum A, Naini AB, Hirano M, Bonilla E, DiMauro S, Vu TH (2002). "Mitochondrial DNA depletion and dGK gene mutations". Ann. Neurol. 52 (3): 311–7. doi:10.1002/ana.10284. PMID 12205643.
• Taanman JW, Kateeb I, Muntau AC, Jaksch M, Cohen N, Mandel H (2002). "A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA". Ann. Neurol. 52 (2): 237–9. doi:10.1002/ana.10247. PMID 12210798.
• Krawiec K, Kierdaszuk B, Shugar D (2003). "Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases". Biochem. Biophys. Res. Commun. 301 (1): 192–7. doi:10.1016/S0006-291X(02)03007-3. PMID 12535661.
• Wang L, Limongelli A, Vila MR, Carrara F, Zeviani M, Eriksson S (2005). "Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes". Mol. Genet. Metab. 84 (1): 75–82. doi:10.1016/j.ymgme.2004.09.005. PMID 15639197.
• Mancuso M, Ferraris S, Pancrudo J, Feigenbaum A, Raiman J, Christodoulou J, Thorburn DR, DiMauro S (2005). "New DGK gene mutations in the hepatocerebral form of mitochondrial DNA depletion syndrome". Arch. Neurol. 62 (5): 745–7. doi:10.1001/archneur.62.5.745. PMID 15883261.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Fyrberg A, Mirzaee S, Lotfi K (2007). "Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells". Nucleosides Nucleotides Nucleic Acids. 25 (9–11): 1201–4. doi:10.1080/15257770600894386. PMID 17065091.
• Mousson de Camaret B, Taanman JW, Padet S, Chassagne M, Mayençon M, Clerc-Renaud P, Mandon G, Zabot MT, Lachaux A, Bozon D (2007). "Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion". Biochem. J. 402 (2): 377–85. doi:10.1042/BJ20060705. PMC 1798436. PMID 17073823.
• Franco M, Johansson M, Karlsson A (2007). "Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells". Exp. Cell Res. 313 (12): 2687–94. doi:10.1016/j.yexcr.2007.04.003. PMID 17490647.

External links

• GeneReview/NIH/UW entry on DGUOK-Related Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form