DLX2

DLX2
Identifiers
Aliases	DLX2, TES-1, TES1, AW121999, Dlx-2, distal-less homeobox 2
External IDs	MGI: 94902 HomoloGene: 3244 GeneCards: DLX2
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • protein binding • single-stranded RNA binding Cellular component • nucleus Biological process • cerebral cortex GABAergic interneuron differentiation • proximal/distal pattern formation • cell differentiation • regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • branching morphogenesis of a nerve • embryonic skeletal system development • multicellular organism development • odontogenesis of dentin-containing tooth • cerebral cortex GABAergic interneuron fate commitment • cartilage development • brain development • negative regulation of oligodendrocyte differentiation • forebrain neuron differentiation • embryonic cranial skeleton morphogenesis • olfactory bulb development • hippocampus development • subpallium development • negative regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1746	13392
Ensembl	ENSG00000115844	ENSMUSG00000023391
UniProt	Q07687	P40764
RefSeq (mRNA)	NM_004405	NM_010054
RefSeq (protein)	NP_004396.1 NP_004396.1	NP_034184.1
Location (UCSC)	Chr 2: 172.1 – 172.1 Mb	Chr 2: 71.54 – 71.55 Mb
PubMed search	[1]	[2]
Wikidata

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Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.^[3][4]

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.^[4]

Interactions

DLX2 has been shown to interact with DLX5,^[5] MSX1^[5] and Msh homeobox 2.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics. 13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID 1354641.
4. "Entrez Gene: DLX2 distal-less homeobox 2".
5. Zhang, H; Hu G; Wang H; Sciavolino P; Iler N; Shen M M; Abate-Shen C (May 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. UNITED STATES. 17 (5): 2920–32. doi:10.1128/mcb.17.5.2920. ISSN 0270-7306. PMC 232144. PMID 9111364.

Further reading

• Harris SE, Guo D, Harris MA, et al. (2003). "Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors". Front. Biosci. 8: s1249–65. doi:10.2741/1170. PMID 12957859.
• Qiu M, Bulfone A, Martinez S, et al. (1995). "Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain". Genes Dev. 9 (20): 2523–38. doi:10.1101/gad.9.20.2523. PMID 7590232.
• Selski DJ, Thomas NE, Coleman PD, Rogers KE (1993). "The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue". Gene. 132 (2): 301–3. doi:10.1016/0378-1119(93)90212-L. PMID 7901126.
• Simeone A, Acampora D, Pannese M, et al. (1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2250–4. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.
• McGuinness T, Porteus MH, Smiga S, et al. (1996). "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus". Genomics. 35 (3): 473–85. doi:10.1006/geno.1996.0387. PMID 8812481.
• Zhang H, Hu G, Wang H, et al. (1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. 17 (5): 2920–32. doi:10.1128/mcb.17.5.2920. PMC 232144. PMID 9111364.
• Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins". Brain Res. Dev. Brain Res. 130 (2): 217–30. doi:10.1016/S0165-3806(01)00239-5. PMID 11675124.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Espinoza HM, Ganga M, Vadlamudi U, et al. (2005). "Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein". Biochemistry. 44 (10): 3942–54. doi:10.1021/bi048362x. PMID 15751970.