4-hydroxy-tetrahydrodipicolinate reductase

4-hydroxy-tetrahydrodipicolinate reductase
Identifiers
EC number	1.17.1.8
CAS number	9055-46-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) is an enzyme that catalyzes the chemical reaction

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)⁺ + H₂O $\rightleftharpoons$ (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD⁺ or NADP⁺, and H₂O, whereas its 3 products are (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, NADH or NADPH, and H⁺.

This enzyme participates in lysine biosynthesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase. Other names in common use include:

• dihydrodipicolinate reductase,
• dihydrodipicolinic acid reductase, and
• 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase.

References

Further reading

• Farkas W, Gilvarg C (Dec 1965). "The reduction step in diaminopimelic acid biosynthesis". The Journal of Biological Chemistry. 240 (12): 4717–22. PMID 4378965.
• Tamir H (1971). "Dihydrodipicolinic acid reductase (Escherichia coli)". Methods Enzymol. 17B: 134–139. doi:10.1016/0076-6879(71)17030-9.
• Devenish SR, Blunt JW, Gerrard JA (Jun 2010). "NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase". Journal of Medicinal Chemistry. 53 (12): 4808–12. doi:10.1021/jm100349s. PMID 20503968.