B-1,3-galactosyl-O-glycosyl-glycoprotein b-1,6-N-acetylglucosaminyltransferase

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Identifiers
EC number	2.4.1.102
CAS number	95978-15-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102, O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, beta6-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase, core 2 acetylglucosaminyltransferase, core 6-beta-GlcNAc-transferase A, UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R $\rightleftharpoons$ UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R

References

1. Brockhausen, I.; Rachaman, E.S.; Matta, K.L.; Schachter, H. (1983). "The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis". Carbohydr. Res. 120: 3–16. doi:10.1016/0008-6215(83)88002-1. PMID 6226356.
2. Williams, D.; Longmore, G.; Matta, K.L.; Schachter, H. (1980). "Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal β1-3GalNAc(GlcNAc→GalNAc) β6-N-acetylglucosaminyltransferase". J. Biol. Chem. 255: 11253–11261. PMID 6449508.
3. Williams, D.; Schachter, H. (1980). "Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates". J. Biol. Chem. 255: 11247–11252. PMID 6449507.

External links

• Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)