Caspase-2
| Caspase-2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.22.55 | ||||||||
| CAS number | 182372-14-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Caspase-2 (EC 3.4.22.55, ICH-1, NEDD-2, caspase-2L, caspase-2S, neural precursor cell expressed developmentally down-regulated protein 2, CASP-2, NEDD2 protein) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-
Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).
References
- ↑ Kumar, S.; Kinoshita, M.; Noda, M.; Copeland, N.G.; Jenkins, N.A. (1994). "Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme". Genes Dev. 8 (14): 1613–1626. doi:10.1101/gad.8.14.1613. PMID 7958843.
- ↑ Wang, L.; Miura, M.; Bergeron, L.; Zhu, H.; Yuan, J. (1994). "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death". Cell. 78: 739–750. doi:10.1016/S0092-8674(94)90422-7. PMID 8087842.
- ↑ Li, H.; Bergeron, L.; Cryns, V.; Pasternack, M.S.; Zhu, H.; Shi, L.; Greenberg, A.; Yuan, J. (1997). "Activation of caspase-2 in apoptosis". J. Biol. Chem. 272 (34): 21010–21017. doi:10.1074/jbc.272.34.21010. PMID 9261102.
- ↑ Mancini, M.; Machamer, C.E.; Roy, S.; Nicholson, D.W.; Thornberry, N.A.; Casciola-Rosen, L.A.; Rosen, A. (2000). "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis". J. Cell Biol. 149: 603–612. doi:10.1083/jcb.149.3.603. PMC 2174848
. PMID 10791974. - ↑ Zhivotovsky, B.; Orrenius, S. (2005). "Caspase-2 function in response to DNA damage". Biochem. Biophys. Res. Commun. 331: 859–867. doi:10.1016/j.bbrc.2005.03.191. PMID 15865942.
- ↑ Chang, H.Y.; Yang, X. (2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiol. Mol. Biol. Rev. 64 (4): 821–846. doi:10.1128/mmbr.64.4.821-846.2000. PMID 11104820.
External links
- Caspase-2 at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/17/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.