Ethacridine lactate

Ethacridine lactate
Skeletal formulas of ethacridine lactate
Ball-and-stick models of the component ions of ethacridine lactate
Clinical data
AHFS/Drugs.com International Drug Names
ATC code B05CA08 (WHO) D08AA01 (WHO)
Identifiers
CAS Number 1837-57-6 N
PubChem (CID) 15789
ChemSpider 15012 YesY
KEGG D01248 YesY
ChEMBL CHEMBL582355 YesY
ECHA InfoCard 100.015.826
Chemical and physical data
Formula C18H21N3O4
Molar mass 343.37
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an antiseptic in solutions of 0.1%.It is effective against mostly gram-positive species like Streptococci and Staphylococci and ineffective against gram-negative(Pseudomonas aeruginosa).

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

References

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