Ethacridine lactate
Clinical data | |
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AHFS/Drugs.com | International Drug Names |
ATC code | B05CA08 (WHO) D08AA01 (WHO) |
Identifiers | |
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CAS Number | 1837-57-6 |
PubChem (CID) | 15789 |
ChemSpider | 15012 |
KEGG | D01248 |
ChEMBL | CHEMBL582355 |
ECHA InfoCard | 100.015.826 |
Chemical and physical data | |
Formula | C18H21N3O4 |
Molar mass | 343.37 |
3D model (Jmol) | Interactive image |
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Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.
Its primary use is as an antiseptic in solutions of 0.1%.It is effective against mostly gram-positive species like Streptococci and Staphylococci and ineffective against gram-negative(Pseudomonas aeruginosa).
Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used. Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.
References
- Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and gynecology. 61 (6): 733–736. PMID 6843933.
- Merck Index, 11th Ed., 3668.
- Adarchenko AA, Krasil'nikov AP, Sobeshchuk OP (1989). "[Antiseptic sensitivity of clinical strains of Pseudomonas aeruginosa]". Antibiotiki i Khimioterapiia (in Russian). 34 (12): 902–7. PMID 2517004.