FCRL4

FCRL4
Identifiers
Aliases	FCRL4, CD307d, FCRH4, IGFP2, IRTA1, Fc receptor like 4
External IDs	HomoloGene: 88926 GeneCards: FCRL4
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • plasma membrane • extracellular exosome • membrane Biological process • adaptive immune response • immune system process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	83417	n/a
Ensembl	ENSG00000163518	n/a
UniProt	Q96PJ5	n/a
RefSeq (mRNA)	NM_031282	n/a
RefSeq (protein)	NP_112572.1	n/a
Location (UCSC)	Chr 1: 157.57 – 157.6 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues.^[2][3][4]

References

1. "Human PubMed Reference:".
2. Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R (Apr 2001). "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy". Immunity. 14 (3): 277–89. doi:10.1016/S1074-7613(01)00109-1. PMID 11290337.
3. Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
4. "Entrez Gene: FCRL4 Fc receptor-like 4".

Further reading

• Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.
• Ehrhardt GR, Hsu JT, Gartland L, et al. (2005). "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells". J. Exp. Med. 202 (6): 783–91. doi:10.1084/jem.20050879. PMC 2212938. PMID 16157685.
• Jöhrens K, Shimizu Y, Anagnostopoulos I, et al. (2006). "T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution". Haematologica. 90 (8): 1070–7. PMID 16079106.
• Falini B, Tiacci E, Pucciarini A, et al. (2004). "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)". Blood. 102 (10): 3684–92. doi:10.1182/blood-2003-03-0750. PMID 12881317.
• Guselnikov SV, Ershova SA, Mechetina LV, et al. (2002). "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1". Immunogenetics. 54 (2): 87–95. doi:10.1007/s00251-002-0436-x. PMID 12037601.
• Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.