Feline sarcoma oncogene

FES
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WQU, 2DCR, 3BKB, 3CBL, 3CD3, 4DYL, 4E93
Identifiers
Aliases	FES, FPS, Feline sarcoma oncogene, FES proto-oncogene, tyrosine kinase
External IDs	MGI: 95514 HomoloGene: 37563 GeneCards: FES
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • microtubule binding • immunoglobulin receptor binding • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein binding • phosphatidylinositol binding • ATP binding • lipid binding • protein tyrosine kinase activity Cellular component • cytoplasm • cytosol • Golgi apparatus • membrane • focal adhesion • microtubule cytoskeleton • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • cytoplasmic, membrane-bounded vesicle • cell junction • cytoskeleton • cytoplasmic vesicle Biological process • centrosome organization • phosphorylation • regulation of vesicle-mediated transport • regulation of cell motility • multicellular organism development • chemotaxis • protein phosphorylation • regulation of cell adhesion • regulation of cell proliferation • microtubule bundle formation • regulation of cell shape • positive regulation of neuron projection development • positive regulation of microtubule polymerization • peptidyl-tyrosine autophosphorylation • regulation of cell differentiation • protein autophosphorylation • peptidyl-tyrosine phosphorylation • regulation of mast cell degranulation • cell proliferation • innate immune response • positive regulation of actin cytoskeleton reorganization • positive regulation of myeloid cell differentiation • epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2242	14159
Ensembl	ENSG00000182511	ENSMUSG00000053158
UniProt	P07332	P16879
RefSeq (mRNA)	NM_001143783 NM_001143784 NM_001143785 NM_002005	NM_010194
RefSeq (protein)	NP_001137255.1 NP_001137256.1 NP_001137257.1 NP_001996.1	NP_034324.2
Location (UCSC)	Chr 15: 90.88 – 90.9 Mb	Chr 7: 80.38 – 80.39 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.^[3][4] FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.^[5]

Function

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.^[4]

Interactions

Feline sarcoma oncogene has been shown to interact with BCAR1^[6] and BCR gene.^[7][8]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Bowden DW, Akots G, Rothschild CB (Aug 1991). "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Research. 19 (15): 4311. doi:10.1093/nar/19.15.4311. PMC 328602. PMID 1870997.
4. "Entrez Gene: FES feline sarcoma oncogene".
5. Craig AW (2012). "FES/FER kinase signaling in hematopoietic cells and leukemias". Frontiers in Bioscience. 17: 861–75. doi:10.2741/3961. PMID 22201778.
6. Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA (Jan 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". The Journal of Biological Chemistry. 272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. PMID 8999909.
7. Lionberger JM, Smithgall TE (Feb 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Research. 60 (4): 1097–103. PMID 10706130.
8. Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE (Feb 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and Cellular Biology. 15 (2): 835–42. PMC 231961. PMID 7529874.

Further reading

• Smithgall TE, Rogers JA, Peters KL, Li J, Briggs SD, Lionberger JM, Cheng H, Shibata A, Scholtz B, Schreiner S, Dunham N (1998). "The c-Fes family of protein-tyrosine kinases". Critical Reviews in Oncogenesis. 9 (1): 43–62. doi:10.1615/critrevoncog.v9.i1.40. PMID 9754447.
• Jiang H, Harris MB, Rothman P (Jun 2000). "IL-4/IL-13 signaling beyond JAK/STAT". The Journal of Allergy and Clinical Immunology. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136.
• Greer P (Apr 2002). "Closing in on the biological functions of Fps/Fes and Fer". Nature Reviews Molecular Cell Biology. 3 (4): 278–89. doi:10.1038/nrm783. PMID 11994747.