Ficolin

Ficolins (Fi+Col+Lin) are a group of oligomeric lectins with subunits consisting of both collagen (Col)-like long thin stretches and fibrinogen (Fi)-like globular domains with lectin (Lin) activity usually specific for N-acetylglucosamine (GlcNAc).^[1] Like collectins (Col+lectin) such as mannan-binding lectin, ficolins are secreted, lectin-type pattern recognition receptors, and similarly activate the lectin pathway of complement activation.

Examples of human ficolins include:

Immunologist Jeak L. Ding and her team found that natural IgG (nIgG; a non-specific immunoglobulin of adaptive immunity) is not quiescent, but plays a crucial role in immediate immune defense by collaborating with ficolin (an innate immune protein).

References

↑ Matsushita, Misao (2010). "Ficolins: Complement-Activating Lectins Involved in Innate Immunity". Journal of Innate Immunity. 2 (1): 24–32. doi:10.1159/000228160. PMID 20375620.

Protein: lectins

Animal

C-type lectins	Asialoglycoprotein receptor KLRD1 Collectin Mannan-binding lectin Mannose receptor proteochondroitin sulfate Aggrecan Versican Brevican Neurocan

Other	Calnexin Calreticulin CD22 CD33 Galectin Myelin-associated glycoprotein N-Acetylglucosamine receptor Selectin Sialoadhesin

Plant

Proteins: complement system (C, L, A)

Activators/enzymes

Early	C: C1Q/C1R/C1S C4 C4a C4b C2 L: MASP1/MASP2 MBL A: Factor B Factor D Factor P/Properdin

Middle	C3 C3a C3b/iC3b C5 C5a C3-convertase C5-convertase

Late	MAC C6 C7 C8 C9

Inhibitors

CL: C4BP

A: Factor H

Complement receptors

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