Fixed-dose combination (antiretroviral)
Fixed-dose combinations of antiretrovirals are multiple antiretroviral drugs combined into a single pill, which helps reduce pill burden. They may combine different classes of antiretrovirals or contain only a single class. Licensed fixed-dose combinations are shown in the table below. Six are complete single-tablet regimens for the treatment of HIV (Atripla, Complera/Eviplera, Stribild, Triumeq, Genvoya, Odefsey); the others must be combined with one or more additional pills to complete a regimen.
Brand Name | Drug Names (INN) | Date of FDA Approval | Company |
---|---|---|---|
Combivir | lamivudine + zidovudine | September 26, 1997 | GlaxoSmithKline |
Kaletra | lopinavir + ritonavir | September 15, 2000 | Abbott Laboratories |
Trizivir | abacavir + lamivudine + zidovudine | November 15, 2000 | GlaxoSmithKline |
Epzicom (U.S.) Kivexa (EU, RU) | abacavir + lamivudine | August 2, 2004 | GlaxoSmithKline |
Truvada | tenofovir disoproxil + emtricitabine | August 2, 2004 | Gilead Sciences |
Atripla | emtricitabine + tenofovir disoproxil + efavirenz | July 12, 2006 | Gilead Sciences and Bristol-Myers Squibb |
Complera (U.S.) Eviplera (EU, RU) | emtricitabine + rilpivirine + tenofovir disoproxil | August 10, 2011 | Gilead Sciences and Janssen Therapeutics (formerly Tibotec) |
Stribild | elvitegravir + cobicistat + emtricitabine + tenofovir disoproxil | August 27, 2012 | Gilead Sciences |
Triumeq | abacavir + dolutegravir + lamivudine | August 22, 2014 | ViiV Healthcare |
Evotaz | atazanavir + cobicistat | January 29, 2015 | Bristol-Myers Squibb |
Prezcobix | darunavir + cobicistat | January 29, 2015 | Janssen Therapeutics |
Dutrebis | lamivudine + raltegravir | February 6, 2015 | Merck & Co. |
Genvoya | elvitegravir + cobicistat + emtricitabine + tenofovir alafenamide | November 5, 2015 | Gilead Sciences |
Odefsey | emtricitabine + rilpivirine + tenofovir alafenamide | March 1, 2016 | Gilead Sciences |
Descovy | emtricitabine + tenofovir alafenamide | April 4, 2016 | Gilead Sciences |
See also
References
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