Gem-associated protein 5

GEMIN5
Identifiers
Aliases GEMIN5, GEMIN-5, gem nuclear organelle associated protein 5
External IDs MGI: 2449311 HomoloGene: 9155 GeneCards: GEMIN5
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

25929

216766

Ensembl

ENSG00000082516

ENSMUSG00000037275

UniProt

Q8TEQ6

Q8BX17

RefSeq (mRNA)

NM_015465
NM_001252156

NM_001166669
NM_001166670
NM_001166671
NM_172558

RefSeq (protein)

NP_001239085.1
NP_056280.2

NP_001160141.1
NP_001160142.1
NP_001160143.1
NP_766146.2

Location (UCSC) Chr 5: 154.89 – 154.94 Mb Chr 11: 58.12 – 58.17 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.[3][4]

Function

Gem-associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[4]

Interactions

GEMIN5 has been shown to interact with DDX20[3][5] and SMN1.[3]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 3 Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
  4. 1 2 "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5".
  5. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365Freely accessible. PMID 11914277.

Further reading


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