GEMIN8

GEMIN8
Identifiers
Aliases	GEMIN8, FAM51A1, gem nuclear organelle associated protein 8
External IDs	MGI: 2384300 HomoloGene: 9882 GeneCards: GEMIN8
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • SMN complex • SMN-Sm protein complex • cytosol • nucleus • Gemini of coiled bodies Biological process • mRNA processing • RNA splicing • spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54960	237221
Ensembl	ENSG00000046647	ENSMUSG00000040621
UniProt	Q9NWZ8	Q8BHE1
RefSeq (mRNA)	NM_001042479 NM_001042480 NM_017856	NM_146238 NM_001310722 NM_001310724
RefSeq (protein)	NP_001035944.1 NP_001035945.1 NP_060326.1	NP_001297651.1 NP_001297653.1 NP_666350.2
Location (UCSC)	Chr X: 14.01 – 14.03 Mb	Chr X: 166.17 – 166.19 Mb
PubMed search	[1]	[2]
Wikidata

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Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.^[3][4]

Function

Gemin-8 is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. Gemin-8 binds to both SMN1 and the GEMIN6 / GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: gem (nuclear organelle) associated protein 8".
4. Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L (March 2006). "Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly". J. Biol. Chem. 281 (12): 8126–34. doi:10.1074/jbc.M512243200. PMID 16434402.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Carissimi C, Saieva L, Gabanella F, Pellizzoni L (2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex.". J. Biol. Chem. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.