GGA3

GGA3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases GGA3
External IDs MGI: 2384159 HomoloGene: 121703 GeneCards: GGA3
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

23163

260302

Ensembl

ENSG00000125447

ENSMUSG00000020740

UniProt

Q9NZ52

Q8BMI3

RefSeq (mRNA)

NM_001252067
NM_173048

RefSeq (protein)

NP_766636.2

Location (UCSC) Chr 17: 75.24 – 75.26 Mb Chr 11: 115.58 – 115.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.[3][4]

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.[5]

Interactions

GGA3 has been shown to interact with ARF1[3][6] and ARF3.[4][7]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (May 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J Cell Biol. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099Freely accessible. PMID 10747089.
  4. 1 2 Boman AL, Zhang C, Zhu X, Kahn RA (Jul 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol Biol Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844Freely accessible. PMID 10749927.
  5. "Entrez Gene: GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3".
  6. Puertollano, R; Randazzo P A; Presley J F; Hartnell L M; Bonifacino J S (Apr 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. United States. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. ISSN 0092-8674. PMID 11301005.
  7. Boman, Annette L; Salo Paul D; Hauglund Melissa J; Strand Nicole L; Rensink Shelly J; Zhdankina Olga (Sep 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Mol. Biol. Cell. United States. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. ISSN 1059-1524. PMC 124144Freely accessible. PMID 12221117.

Further reading


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