GGTLA1

GGT5
Identifiers
Aliases	GGT5, GGT-REL, GGTLA1, GGL, GGT 5, gamma-glutamyltransferase 5
External IDs	MGI: 1346063 HomoloGene: 55802 GeneCards: GGT5
EC number	3.4.19.14
Gene ontology Molecular function • transferase activity • glutathione hydrolase activity • peptidase activity • gamma-glutamyltransferase activity • transferase activity, transferring acyl groups • hydrolase activity Cellular component • integral component of membrane • plasma membrane • anchored component of external side of plasma membrane • membrane Biological process • cellular amino acid metabolic process • leukotriene metabolic process • glutathione biosynthetic process • inflammatory response • leukotriene biosynthetic process • glutathione metabolic process • proteolysis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2687	23887
Ensembl	ENSG00000099998	ENSMUSG00000006344
UniProt	P36269	Q9Z2A9
RefSeq (mRNA)	NM_001099781 NM_001099782 NM_001302464 NM_001302465 NM_004121	NM_011820
RefSeq (protein)	NP_001093251.1 NP_001093252.1 NP_001289393.1 NP_001289394.1 NP_004112.2	NP_035950.2
Location (UCSC)	Chr 22: 24.22 – 24.25 Mb	Chr 10: 75.59 – 75.62 Mb
PubMed search	[1]	[2]
Wikidata

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Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.^[3][4][5][6]

Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (Aug 1991). "Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase". Proc Natl Acad Sci U S A. 88 (14): 6303–7. doi:10.1073/pnas.88.14.6303. PMC 52071. PMID 1676842.
4. Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet. 91 (1): 31–6. doi:10.1007/bf00230218. PMID 8095916.
5. Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet. 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469.
6. "Entrez Gene: GGTLA1 gamma-glutamyltransferase-like activity 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Enoiu M, Aberkane H, Salazar JF, et al. (2000). "Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme.". Free Radic. Biol. Med. 29 (9): 825–33. doi:10.1016/S0891-5849(00)00370-1. PMID 11063908.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Edelmann L, Pandita RK, Morrow BE (2000). "Low-copy repeats mediate the common 3-Mb deletion in patients with velo-cardio-facial syndrome.". Am. J. Hum. Genet. 64 (4): 1076–86. doi:10.1086/302343. PMC 1377832. PMID 10090893.
• Potdar PD, Andrews KL, Nettesheim P, Ostrowski LE (1997). "Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells.". Am. J. Physiol. 273 (5 Pt 1): L1082–9. PMID 9374738.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.