GLE1L

GLE1
Identifiers
Aliases GLE1, GLE1L, LCCS, LCCS1, hRNA export mediator
External IDs MGI: 1921662 HomoloGene: 20379 GeneCards: GLE1
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

2733

74412

Ensembl

ENSG00000119392

ENSMUSG00000019715

UniProt

Q53GS7

Q8R322

RefSeq (mRNA)

NM_001003722
NM_001499

NM_028923

RefSeq (protein)

NP_001003722.1
NP_001490.1

NP_083199.1

Location (UCSC) Chr 9: 128.5 – 128.54 Mb Chr 2: 29.94 – 29.96 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin GLE1 is a protein that in humans is encoded by the GLE1 gene on chromosome 9.[3][4][5]

Function

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

Clinical significance

A genome-wide screening and linkage analysis assigned the disease locus of lethal congenital contracture syndrome, one of 40 Finnish heritage diseases, to a defined region of 9q34, where the GLE1 gene is located.[6] Mutations in GLEI have been identified in families with foetal motoneuron disease.[7]

Interactions

GLE1L has been shown to interact with NUP155.[8]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Watkins JL, Murphy R, Emtage JL, Wente SR (Jul 1998). "The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export". Proc Natl Acad Sci U S A. 95 (12): 6779–84. doi:10.1073/pnas.95.12.6779. PMC 22633Freely accessible. PMID 9618489.
  4. Nousiainen HO, Kestilä M, Pakkasjärvi N, Honkala H, Kuure S, Tallila J, Vuopala K, Ignatius J, Herva R, Peltonen L (Jan 2008). "Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease". Nat Genet. 40 (2): 155–7. doi:10.1038/ng.2007.65. PMC 2684619Freely accessible. PMID 18204449.
  5. 1 2 "Entrez Gene: GLE1L GLE1 RNA export mediator-like (yeast)".
  6. Mäkelä-Bengs P, Järvinen N, Vuopala K, Suomalainen A, Palotie A, Peltonen L (1997). "The assignment the lethal congenital contracture syndrome (LCCS) locus to chromosome 9q33-34". Am. J. Hum. Genet. 61 (suppl): A30.
  7. Nousiainen HO, Kestilä M, Pakkasjärvi N, Honkala H, Kuure S, Tallila J, Vuopala K, Ignatius J, Herva R, Peltonen L (February 2008). "Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease". Nature Genetics. 40 (2): 155–157. doi:10.1038/ng.2007.65. PMC 2684619Freely accessible. PMID 18204449.
  8. Rayala HJ, Kendirgi F, Barry DM, Majerus PW, Wente SR (Feb 2004). "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155". Mol. Cell Proteomics. 3 (2): 145–55. doi:10.1074/mcp.M300106-MCP200. PMID 14645504.

Further reading


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