GLRA3

GLRA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CFB
Identifiers
Aliases	GLRA3
External IDs	MGI: 95749 HomoloGene: 142 GeneCards: GLRA3
Targeted by Drug
dronabinol, hu-210, nifedipine, win 55212-2, picrotoxin[1]
Gene ontology Molecular function • glycine-gated chloride ion channel activity • glycine binding • metal ion binding • transmitter-gated ion channel activity • chloride channel activity • extracellular ligand-gated ion channel activity • extracellular-glycine-gated chloride channel activity Cellular component • integral component of membrane • perikaryon • postsynaptic membrane • cell projection • membrane • plasma membrane • synapse • integral component of plasma membrane • chloride channel complex • glycine-gated chloride channel complex • cell junction • dendrite Biological process • response to amino acid • chloride transmembrane transport • ion transport • ion transmembrane transport • transport • synaptic transmission, glycinergic • chloride transport • neuropeptide signaling pathway • protein homooligomerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8001	110304
Ensembl	ENSG00000145451	ENSMUSG00000038257
UniProt	O75311	Q91XP5
RefSeq (mRNA)	NM_001042543 NM_006529	NM_080438
RefSeq (protein)	NP_001036008.1 NP_006520.2	NP_536686.2
Location (UCSC)	Chr 4: 174.64 – 174.83 Mb	Chr 8: 55.94 – 56.13 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

The Glycine receptor subunit alpha-3 is a protein that in humans is encoded by the GLRA3 gene.^[4] The protein encoded by this gene is a subunit of the glycine receptor.^[4]

Variants of this receptor subunit is associated with susceptibility to epilepsy.^[5]

References

1. "Drugs that physically interact with Glycine receptor subunit alpha-3 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Nikolic Z, Laube B, Weber RG, Lichter P, Kioschis P, Poustka A, Mulhardt C, Becker CM (Sep 1998). "The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts". J Biol Chem. 273 (31): 19708–14. doi:10.1074/jbc.273.31.19708. PMID 9677400.
5. Sobetzko D, Sander T, Becker CM (August 2001). "Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies". Am. J. Med. Genet. 105 (6): 534–8. doi:10.1002/ajmg.1488. PMID 11496371.

Further reading

• Breitinger HG, Villmann C, Rennert J, et al. (2002). "Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels.". J. Neurochem. 83 (1): 30–6. doi:10.1046/j.1471-4159.2002.01109.x. PMID 12358726.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053.

External links

• GLRA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)