GLTP

GLTP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SWX, 1SX6, 2EUK, 2EUM, 2EVD, 2EVL, 2EVS, 2EVT, 3RIC, 3RWV, 3RZN, 3S0I, 3S0K, 4GH0, 4GHP, 4GHS, 4GIX, 4GJQ, 4GVT, 4GXD, 4GXG, 4H2Z
Identifiers
Aliases	GLTP
External IDs	MGI: 1929253 HomoloGene: 41133 GeneCards: GLTP
Gene ontology Molecular function • glycolipid binding • protein binding • lipid binding • glycolipid transporter activity Cellular component • cytoplasm • cytosol • extracellular exosome • membrane Biological process • lipid transport • glycolipid transport • glycosphingolipid metabolic process • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51228	56356
Ensembl	ENSG00000139433	ENSMUSG00000011884
UniProt	Q9NZD2	Q9JL62
RefSeq (mRNA)	NM_016433	NM_019821
RefSeq (protein)	NP_057517.1	NP_062795.2
Location (UCSC)	Chr 12: 109.85 – 109.88 Mb	Chr 5: 114.67 – 114.69 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Glycolipid transfer protein is a protein that in humans is encoded by the GLTP gene.^[3][4][5]

The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Li XM, Malakhova ML, Lin X, Pike HM, Chung T, Molotkovsky JG, Brown RE (Aug 2004). "Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy". Biochemistry. 43 (31): 10285–94. doi:10.1021/bi0495432. PMC 2593833. PMID 15287756.
4. Malakhova ML, Malinina L, Pike HM, Kanack AT, Patel DJ, Brown RE (Jul 2005). "Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex". J Biol Chem. 280 (28): 26312–20. doi:10.1074/jbc.M500481200. PMC 1393170. PMID 15901739.
5. "Entrez Gene: GLTP glycolipid transfer protein".

Further reading

• Brown RE, Mattjus P (2007). "Glycolipid transfer proteins.". Biochim. Biophys. Acta. 1771 (6): 746–60. doi:10.1016/j.bbalip.2007.01.011. PMC 1986823. PMID 17320476.
• Abe A (1990). "Primary structure of glycolipid transfer protein from pig brain.". J. Biol. Chem. 265 (17): 9634–7. PMID 2190982.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Mattjus P, Pike HM, Molotkovsky JG, Brown RE (2000). "Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers.". Biochemistry. 39 (5): 1067–75. doi:10.1021/bi991810u. PMC 2637181. PMID 10653652.
• Lin X, Mattjus P, Pike HM, et al. (2000). "Cloning and expression of glycolipid transfer protein from bovine and porcine brain.". J. Biol. Chem. 275 (7): 5104–10. doi:10.1074/jbc.275.7.5104. PMC 2621014. PMID 10671554.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Malinina L, Malakhova ML, Teplov A, et al. (2004). "Structural basis for glycosphingolipid transfer specificity.". Nature. 430 (7003): 1048–53. doi:10.1038/nature02856. PMC 2640488. PMID 15329726.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rao CS, Lin X, Pike HM, et al. (2004). "Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses.". Biochemistry. 43 (43): 13805–15. doi:10.1021/bi0492197. PMC 2596630. PMID 15504043.
• Rao CS, Chung T, Pike HM, Brown RE (2006). "Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition.". Biophys. J. 89 (6): 4017–28. doi:10.1529/biophysj.105.070631. PMC 1366967. PMID 16169991.
• Malinina L, Malakhova ML, Kanack AT, et al. (2006). "The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure.". PLoS Biol. 4 (11): e362. doi:10.1371/journal.pbio.0040362. PMC 1618416. PMID 17105344.