GNAT3

GNAT3
Identifiers
Aliases	GNAT3, GDCA, G protein subunit alpha transducin 3
External IDs	MGI: 3588268 HomoloGene: 24284 GeneCards: GNAT3
Gene ontology Molecular function • signal transducer activity • metal ion binding • nucleotide binding • guanyl nucleotide binding • G-protein coupled receptor binding • G-protein beta/gamma-subunit complex binding • GTP binding • GTPase activity Cellular component • acrosomal vesicle • cytoplasm • axoneme • heterotrimeric G-protein complex • apical plasma membrane • plasma membrane • protein complex Biological process • signal transduction • sensory perception of umami taste • response to nicotine • G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • sensory perception of bitter taste • sensory perception of taste • sensory perception of sweet taste • protein folding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	346562	242851
Ensembl	ENSG00000214415	ENSMUSG00000028777
UniProt	A8MTJ3	Q3V3I2
RefSeq (mRNA)	NM_001102386	NM_001081143
RefSeq (protein)	NP_001095856.1	NP_001074612.1
Location (UCSC)	Chr 7: 80.46 – 80.51 Mb	Chr 5: 17.96 – 18.02 Mb
PubMed search	[1]	[2]
Wikidata

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Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein that in humans is encoded by the GNAT3 gene.^[3]

Gustducin alpha-3 chain is a subunit of the heterotrimeric protein gustducin that is responsible for basic taste.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: guanine nucleotide binding protein".

Further reading

• Oldham WM, Van Eps N, Preininger AM, et al. (2006). "Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.". Nat. Struct. Mol. Biol. 13 (9): 772–7. doi:10.1038/nsmb1129. PMID 16892066.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Rozengurt N, Wu SV, Chen MC, et al. (2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.". Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792–802. doi:10.1152/ajpgi.00074.2006. PMID 16728727.
• Huang L, Shanker YG, Dubauskaite J, et al. (1999). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.". Nat. Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029.
• Margolskee RF, Dyer J, Kokrashvili Z, et al. (2007). "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075–80. Bibcode:2007PNAS..10415075M. doi:10.1073/pnas.0706678104. PMC 1986615. PMID 17724332.
• Takami S, Getchell TV, McLaughlin SK, et al. (1994). "Human taste cells express the G protein alpha-gustducin and neuron-specific enolase.". Brain Res. Mol. Brain Res. 22 (1-4): 193–203. doi:10.1016/0169-328X(94)90047-7. PMID 8015379.
• Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. (2007). "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069–74. Bibcode:2007PNAS..10415069J. doi:10.1073/pnas.0706890104. PMC 1986614. PMID 17724330.
• Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
• Fehr J, Meyer D, Widmayer P, et al. (2007). "Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.". J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 193 (1): 21–34. doi:10.1007/s00359-006-0168-8. PMID 17021831.
• Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). "Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein.". Nature. 369 (6482): 621–8. Bibcode:1994Natur.369..621L. doi:10.1038/369621a0. PMID 8208289.