GPS1

GPS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases GPS1, COPS1, CSN1, SGN1, G protein pathway suppressor 1
External IDs MGI: 2384801 HomoloGene: 3046 GeneCards: GPS1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

2873

209318

Ensembl

ENSG00000169727

ENSMUSG00000025156

UniProt

Q13098

Q99LD4

RefSeq (mRNA)

NM_001177874
NM_145370

RefSeq (protein)

NP_004118.3
NP_997657.1
NP_001308021.1

n/a

Location (UCSC) Chr 17: 82.05 – 82.06 Mb Chr 11: 120.78 – 120.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

COP9 signalosome complex subunit 1 is a protein that in humans is encoded by the GPS1 gene.[3][4]

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
  4. 1 2 "Entrez Gene: GPS1 G protein pathway suppressor 1".

Further reading


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