GSTT1

GSTT1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2C3N, 2C3Q, 2C3T
Identifiers
Aliases	GSTT1
External IDs	GeneCards: GSTT1
Gene ontology Molecular function • transferase activity • glutathione peroxidase activity • glutathione transferase activity Cellular component • cytoplasm • cytosol • extracellular exosome Biological process • glutathione derivative biosynthetic process • glutathione metabolic process • cellular oxidant detoxification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2952	n/a
Ensembl	ENSG00000277656	n/a
UniProt	P30711	n/a
RefSeq (mRNA)	NM_000853 NM_001293807 NM_001293808 NM_001293809 NM_001293810 NM_001293811 NM_001293812 NM_001293813 NM_001293814	n/a
RefSeq (protein)	NP_000844.2 NP_001280736.1 NP_001280737.1 NP_001280738.1 NP_001280739.1 NP_001280740.1 NP_001280741.1	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.^[2]

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.^[3]

References

1. "Human PubMed Reference:".
2. Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
3. "Entrez Gene: GSTT1 glutathione S-transferase theta 1".