GTF2H5

GTF2H5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YDL, 2JNJ, 5IY8, 5IY6, 5IY7, 5IVW, 5IY9
Identifiers
Aliases	GTF2H5, C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A, TTDA, bA120J8.2, TTD3, general transcription factor IIH subunit 5
External IDs	MGI: 107227 HomoloGene: 45635 GeneCards: GTF2H5
Gene ontology Molecular function • rDNA binding Cellular component • nucleoplasm • nucleolus • core TFIIH complex • nucleus Biological process • termination of RNA polymerase I transcription • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription from RNA polymerase II promoter • transcription, DNA-templated • cellular response to DNA damage stimulus • global genome nucleotide-excision repair • transcription elongation from RNA polymerase I promoter • cellular response to gamma radiation • rRNA processing • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • nucleotide-excision repair, DNA incision • nucleotide-excision repair, preincision complex assembly • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA duplex unwinding • DNA repair • nucleotide-excision repair, preincision complex stabilization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	404672	66467
Ensembl	ENSG00000272047	ENSMUSG00000034345
UniProt	Q6ZYL4	Q8K2X8
RefSeq (mRNA)	NM_207118	NM_181392
RefSeq (protein)	NP_997001.1	NP_852057.2
Location (UCSC)	Chr 6: 158.17 – 158.2 Mb	Chr 17: 6.08 – 6.09 Mb
PubMed search	[1]	[2]
Wikidata

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General transcription factor IIH subunit 5 is a protein that in humans is encoded by the GTF2H5 gene.^[3][4]

Interactions

GTF2H5 has been shown to interact with GTF2H2^[3][5] and XPB.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (June 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. doi:10.1038/ng1387. PMID 15220921.
4. "Entrez Gene: GTF2H5 general transcription factor IIH, polypeptide 5".
5. Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM (November 2000). "Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder". Nat. Genet. 26 (3): 307–13. doi:10.1038/81603. PMID 11062469.

Further reading

• Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM (2000). "Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder". Nat. Genet. 26 (3): 307–13. doi:10.1038/81603. PMID 11062469.
• Coin F, Proietti De Santis L, Nardo T, Zlobinskaya O, Stefanini M, Egly JM (2006). "p8/TTD-A as a repair-specific TFIIH subunit". Mol. Cell. 21 (2): 215–26. doi:10.1016/j.molcel.2005.10.024. PMID 16427011.
• Giglia-Mari G, Miquel C, Theil AF, Mari PO, Hoogstraten D, Ng JM, Dinant C, Hoeijmakers JH, Vermeulen W (2006). "Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells". PLoS Biol. 4 (6): e156. doi:10.1371/journal.pbio.0040156. PMC 1457016. PMID 16669699.
• Vitorino M, Coin F, Zlobinskaya O, Atkinson RA, Moras D, Egly JM, Poterszman A, Kieffer B (2007). "Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy". J. Mol. Biol. 368 (2): 473–80. doi:10.1016/j.jmb.2007.02.020. PMID 17350038.